Molecular Pathology
Courses
For course descriptions not found in the 2008-2009 General Catalog, please contact the department for more information.
PATH 208G. Human Disease (8) An integrated consideration of the general principles of pathology and microbiology, epidemiology, and medical therapeutics of the important diseases. An example of their application to a specific organ system will be included. (Not offered in 2006-07.)
PATH 220. Mechanisms of Neurological Disease (4) This course will explore the molecular pathology associated with various diseases other than cancer. Emphasis will be placed on understanding the abberant cellular processes, caused by mutation or environmental factors, that are associated with the disease state. Cardiovascular, neurological, immunological, and other diseases will be investigated.
PATH 221. Molecular Pathology of Cancer (4) The purpose of this course is to present exciting new developments in molecular carcinogenesis, with particular emphasis on oncogene expression and functions of oncogenic proteins. The relevance of molecular mechanisms for understanding human cancer will be discussed.
PATH 222. Microbial Pathogenesis (4) Topics covered in this course include molecular and cellular mechanisms of viral, bacterial, and protozoan pathogenesis. Host response and microbial mechanisms of host defense will also be discussed. Sessions will consist of faculty and student presentations of current literature.
PATH 223. Mouse Models of Human Disease (2) This course provides an overview of the use of mouse models in biomedical research. Sessions will cover general mouse biology, genetics, and technologies for generating mutant mice; and will focus on model selection, methodological approaches, data interpretation, experimental design, and ethics of animal research. Student participation and discussion will be encouraged. Prerequisite: graduate standing or consent of instructor.
PATH 225. Molecular Pathology Research Seminars (2) This course presents developments in cellular and molecular pathology research. Both faculty and students actively participate in the individual sessions. All students are required to give one to two formal presentations (under faculty supervision) during the year. The relevance of molecular mechanisms for understanding human disease will be discussed. Prerequisite: consent of instructor.
PATH 230G. Molecular Biology of the Cell (6) This course offers a concise overview of the biochemical basis of gene expression and of diverse signal transduction pathways, and integrates this background in the context of cellular processes such as cell division, development, cell-cell interactions, and inflammation. This course will highlight recent discoveries in cellular and molecular biology and will highlight human diseases that result from inappropriate regulation of cellular processes.
PATH 231. Modern Methods in Molecular and Cell Biology (4) This course presents key concepts and methodologies used in cellular and molecular pathology research. Topics include protein purification, biochemical characterization, identification of post-translational modifications, DNA/protein microinjection, immunofluorescence, digital imaging, electron microscopy, stem cell culture, gene/promoter analysis, protein-protein interaction analysis using the yeast 2-hybrid system, transgenic and knockout mouse construction, analysis of bacterial virulence factors, and genomic/proteinomic approaches to disease analysis.
PATH 232. Statistical Methods and Experimental Design This course will emphasize the relationships between experimental design, statistical methods, and biomedical research. The content of the course will include basic issues in experimental design and commonly used statistical methods. The assumptions behind the statistical tests, their appropriate use, and examples of misuse will be discussed.
PATH 296. Directed Reading (1-4) Reading and laboratory study of special topics under the direction of a faculty member. Exact subject matter to be arranged in individual cases.
PATH 299. Independent Study or Research (1-12) Independent study or research.
SOM 213. Histology (2) This course teaches the structural basis of normal and abnormal function at the cellular and tissue levels. Emphasis is based on microscopic study conducted in small laboratory groups under close faculty supervision.
SPPS 215. Human Disease (3) This introduction to human disease includes etiology and mechanisms of common disease states and integrates pathology with previous core curriculum. The focus will be to understand disease processes and the dynamics of changes related to drug thearapy. Our goal is to give the student an overview of the illnesses and disorders of human organs, systems and functions, in other words, human disease, with the hope that this background will lead the students to clinical understanding of patients and future insight into the pathogenesis of disease and new treatments. This course will include general pathology and system based pathology, taught in lecture, case discussion, and lab format.
