Chemistry and Biochemistry
Courses
For course descriptions not found in the 2005-2006 General
Catalog, please contact the department for more information.
Lower-Division
4. Basic Chemistry (4) Chemistry 4 is
a one-quarter course for science majors with insufficient preparation
to start the Chem. 6 sequence. Emphasis is on learning how to solve
quantitative problems. Topics include nomenclature, stoichiometry,
and the periodic table. Includes a combined laboratory and discussion-recitation
each week. Prerequisite: Math. 4C. Cannot be taken for credit
after any other chemistry course. Intended for science majors.
(F)
6A. General Chemistry I (4) First quarter
of a three-quarter sequence intended for science and engineering
majors. Topics include: stoichiometry, gas laws, bonding, atomic
theory, quantum theory, and thermochemistry. Three hours lecture,
one hour recitation. Prerequisites: proficiency in high school
chemistry or physics. Math. 10A or 20A or a higher course in the
Math. 10 or 20 sequence (may be taken concurrently). (F,W,S)
6AH. Honors General Chemistry I (4) First
quarter of a three-quarter honors sequence intended for well-prepared
science and engineering majors. Topics include: stoichiometry, gas
laws, bonding, atomic theory, quantum theory, and thermochemistry.
Three hours lecture and one hour recitation. Students may not receive
credit for both Chem. 6AH and Chem. 6A. Prerequisites: proficiency
in high school chemistry, physics and mathematics. Math. 10A or
20A or a higher course in the Math. 10 or 20 sequence. Concurrent
enrollment in Math. 20A or higher level calculus required. (F)
6B. General Chemistry II (4) Second quarter
of a three-quarter sequence intended for science and engineering
majors. Topics include: molecular geometry, condensed phases and
solutions, chemical equilibrium, acids and bases and thermodynamics.
Three hours lecture and one hour recitation. Prerequisites: Chem.
6A, Math. 10A or 20A or a higher course in the Math. 10 or 20 sequence.
(F,W,S)
6BH. Honors General Chemistry II (4) Second
quarter of a three-quarter honors sequence intended for well-prepared
science and engineering majors. Topics include: molecular geometry,
condensed phases and solutions, chemical equilibrium, acids and
bases and thermodynamics. Students may not receive credit for both
Chem. 6BH and Chem. 6B. Three hours lecture and one hour recitation.
Prerequisites: Chem. 6AH, Math. 10A or 20A or a higher course
in the Math. 10 or 20 sequence. (W)
6BL. Introductory Inorganic Chemistry Laboratory (3) Introduction
to experimental procedures used in synthetic, inorganic, analytical,
and physical chemistry. Prerequisites: Chem. 6A, 6B. If 6BL is
a requirement for your major, it should be taken concurrently with
6C. A materials fee is required for this course. (F,W,S)
6C. General Chemistry III (4) Third quarter
of a three-quarter sequence intended for science and engineering
majors. Topics include: electrochemistry, kinetics, coordination
chemistry, nuclear chemistry, and an introduction to organic and
biochemistry. Three hours lecture and one hour recitation. Prerequisite:
Chem. 6B; Chem. 6BL may be taken concurrently. (F,W,S)
6CH. Honors General Chemistry III (4) Third
quarter of a three-quarter honors sequence intended for well-prepared
science and engineering majors. Topics include: electrochemistry,
kinetics, coordination chemistry, nuclear chemistry, and an introduction
to organic and biochemistry. Three hours lecture and one hour recitation.
Students may not receive credit for both Chem. 6CH or Chem. 6C.
Prerequisites: Chem. 6BH, Math. 20B; Chem. 6BL may be taken concurrently.
(S)
11. The Periodic Table (4) Introduction
to the material world of atoms and small inorganic molecules. Intended
for nonscience majors. Can be skipped by students with a good knowledge
of high school chemistry. Cannot be taken for credit after any other
general chemistry course. (F)
12. Molecules and Reactions (4) Introduction
to molecular bonding and structure and chemical reactions, including
organic molecules and synthetic polymers. Intended for nonscience
majors. Prerequisite: Chem. 11 or good knowledge of high school
chemistry. Cannot be taken for credit after any organic chemistry
course. (W)
13. Chemistry of Life (4) Introduction
to biochemistry for nonscience majors. Prerequisite: Chem. 12.
Cannot be taken for credit after any biochemistry course. (S)
15. Chemistry of the Universe (4) This
is a one-quarter, nonmathematical chemistry course for nonscience
majors covering the origin of the universe, the elements, and the
formation of the solar system. The evolution of the Earths
atmosphere, hydrosphere, geosphere, and biosphere will be covered,
as well as contemporary problems in environmental chemistry. Cannot
be taken for credit after any other chemistry course.
87. Freshman Seminar in Chemistry and Biochemistry (1) This
seminar will present topics in chemistry at a level appropriate
for first-year students.
90. Undergraduate Seminar (1) The seminar
will focus on a variety of issues and special areas in the field
of chemistry.
91. Undergraduate Honors Seminar (1) A
seminar intended for exposing undergraduate students, especially
freshmen and sophomores, to exciting research programs conducted
by the faculty. Enrollment is limited.
92. Undergraduate Pharmacology Seminar (1) Selected
topics in pharmacology and toxicology.
99. Independent Study (2-4) Independent
literature or laboratory research by arrangement with and under
the direction of a member of the Department of Chemistry and Biochemistry
faculty. Students must register on a P/NP basis. Prerequisites:
lower-division standing, 3.0 minimum UCSD GPA, consent of instructor
and department, completion of 30 units of undergraduate study at
UCSD, completed and approved special studies form.
Upper-Division
100A. Analytical Chemistry Laboratory (4)
Laboratory course emphasizing classical quantitative
chemical analysis techniques, including separation and gravimetric
methods, as well as an introduction to instrumental analysis. Prerequisites:
CHEM 6C or 6CH or equivalent, and CHEM 6BL or equivalent; PHYS 2CL
or 2BL recommended. A materials fee is required for this course.
100B. Instrumental Analysis Laboratory (4) Laboratory
course covering fundamental principles of operation, capabilities,
applications, and limitations of modern analytical instrumentation.
Techniques include gas chromatography, mass spectrometry, high performance
liquid chromatography, ion chromatography, atomic absorption spectroscopy,
fluorescence, and infrared spectrometry. Prerequisites: Chem.
100A, and Phys.2A-B-D or equivalent; Phys.2CL or 2BL recommended.
A materials fee is required for this course.
105A. Physical Chemistry Laboratory (5) Laboratory
course in experimental physical chemistry. Prerequisites: Chem.100A
and Phys. 2CL or equivalent, Chem. 126 or 127 or 131 or 133.
A materials fee is required for this course. (F,W,S)
105B. Physical Chemistry Laboratory (4) Laboratory
course in experimental physical chemistry. Prerequisite: Chem.
105A. A materials fee is required for this course. (F,W,S)
107. Synthetic Macromolecules (4) The
chemistry of high polymers with emphasis on synthesis, structure,
characterization, and properties. Polymers as materials are important
as films, fibers, and elastomers. They play an ever-increasing role
in science, technology, and medicine. Prerequisites: Chem. 140AB
or 141AB. (May not be offered every year.)
112A. Molecular Biochemistry Laboratory (6) The
application of techniques to study protein structure and function,
including electrophoresis, protein purification, column chromatography,
enzyme kinetics, and immunochemistry. Prerequisites: Chem. 140A-B-C,
143A-B, 114A-B. (Some of these courses may be taken concurrently.)
(Note: Students may not receive credit for both Chem. 112A and BIBC
103.) A materials fee is required for this course. (W)
112B. Molecular Biochemistry Laboratory (6) This
laboratory will introduce the students to the tools of molecular
biology and will involve experiments with recombinant DNA techniques.
Prerequisites: Chem. 114A-B, Chem. 114C (may be taken concurrently);
Chem. 143A and 143B. (Note: Students may not receive credit
for both Chem. 112B and BIMM 101.) A materials fee is required for
this course. (S)
113. Chemistry of Biological Macromolecules (4) A
discussion of the structural principles governing biological macromolecules,
the techniques used in their study, and how their functional properties
depend on three-dimensional structure. Prerequisites: elementary
organic and physical chemistry. (May not be offered every year.)
114A. Biochemical Structure and Function (4) Introduction
to biochemistry from a structural and functional viewpoint. Prerequisite:
elementary organic chemistry (Chem. 140A or equivalent). (Note:
Students may not receive credit for both Chem. 114A and BIBC 100.)
(F)
114B. Biochemical Energetics and Metabolism (4) This
course is an introduction to the metabolic reactions in the cell
which produce and utilize energy. The course material will include
energy-producing pathways: glycolysis, Krebs cycle, oxidative phosphorylation,
fatty-acid oxidation. Biosynthesis of amino acids, lipids, carbohydrates,
purines, pyrimidines, proteins, nucleic acids. Prerequisite:
Chem. 114A or BIBC 100. (Note: Students may not receive credit
for both Chem. 114B and BIBC 102) (W)
114C. Biosynthesis of Macromolecules (4) This
course is a continuation of the introduction to biochemistry courses
(114A and 114B). This quarter reviews the mechanisms of biosynthesis
of macromoleculesparticularly proteins and nucleic acids.
Emphasis will be placed on how these processes are controlled and
integrated with the metabolism of the cell. Prerequisite: Chem.
114B or BIBC 102. (Note: Students may not receive credit for
both Chem. 114C and BIMM 100.) (S)
114D. Molecular and Cellular Biochemistry (4) This
course represents a continuation of 114C, or an introductory course
for first- and second-year graduate students, and covers topics
in molecular and cellular biochemistry. Emphasis will be placed
on contemporary approaches to the isolation and characterization
of mammalian genes and proteins, and molecular genetic approaches
to understanding eukaryotic development and human disease. Prerequisites:
Chem. 114A-C or consent of instructor. (May not be offered every
year.)
115. Modeling Biological Macromolecules (4) Use
of computer graphics and modeling methods in the study of biological
macromolecules. The course will cover basic methods and techniques.
The objective is to provide a good working knowledge of the critical
features of the methods and to provide a foundation for further
study for those who wish to pursue these methods as research topics.
Prerequisite: Chem. 114A or equivalent. (May not be offered
every year.)
116. Chemistry of Enzyme Catalyzed Reactions (4) A
discussion of the chemistry of representative enzyme catalyzed reactions
is presented. Enzyme reaction mechanisms and their relation to enzyme
structure are emphasized. Prerequisites: Chem. 140A-C, 114A,
and 126 or 131. (May not be offered every year.)
118. Pharmacology and Toxicology (4) A
survey of the biochemical action of drugs and toxins as well as
their absorption and excretion. Prerequisites: Chem. 140C or
141C; and Chem. 114C or consent of instructor. Priorities will be
given to PharmChem majors.
120A. Inorganic Chemistry I (4) The chemistry
of the main group elements in terms of atomic structure, ionic and
covalent bonding. Structural theory involving s, p, and unfilled
d orbitals. Thermodynamic and spectroscopic criteria for structure
and stability of compounds and chemical reactions of main group
elements in terms of molecular structure and reactivity. Prerequisites:
a general chemistry course. Chem. 140A or 141A or equivalent course
is recommended. (F)
120B. Inorganic Chemistry II (4) A continuation
of the discussion of structure, bonding, and reactivity with emphasis
on transition metals and other elements using filled d orbitals
to form bonds. Coordination chemistry in terms of valence bond,
crystal field, and molecular orbital theory. The properties and
reactivities of transition metal complexes including organometallic
compounds. Prerequisite: Chem. 120A. (W)
123. Advanced Inorganic Chemistry Laboratory (4) Synthesis,
analysis, and physical characterization of inorganic chemical compounds.
A materials fee is required for this course. Prerequisites:
Chem. 120A, 143AM or 143A, and 143B. Chem. 120B and 143B may be
taken concurrently. (W,S)
124. Bioinorganic Chemistry (4) The role
of metal ions in biological systems, with emphasis on transition
metal ions in enzymes that transfer electrons, bind oxygen, and
fix nitrogen. Also included are metal complexes in medicine, toxicity,
and metal ion storage and transport. Prerequisites: Chem. 6C
or 6CH, 114A, and 120A recommended. (May not be offered every
year.)
126. Physical Chemistry (4) An introduction
to physical chemistry with emphasis on biochemical and environmental
applications. Quantum mechanics and molecular structure, spectroscopy.
Prerequisites: Phys. 2D, Math. 20D or 21D; or consent of instructor.
(F)
127. Physical Chemistry (4) An introduction
to physical chemistry with emphasis on biochemical and environmental
applications. Thermodynamics, first and second laws, thermochemistry,
chemical equilibrium, solutions, kinetic theory, reaction kinetics.
Prerequisite: Chem. 126 or consent of instructor. (W)
131. Physical Chemistry (4) Thermodynamics,
chemical equilibrium, phase equilibrium, chemistry of solutions.
Prerequisites:Math. 20C or 21C, and Phys. 2B. Recommended: Math.
20D or 21D, and Phys. 2D. (F)
132. Physical Chemistry (4) Chemical statistics,
kinetic theory, reaction kinetics. Prerequisites: Math. 20D or
21D, and Phys. 2B. Recommended: Phys. 2D. (W)
133. Physical Chemistry (4) Quantum mechanics,
atomic and molecular spectroscopy, molecular structure. Prerequisites:
Chem. 132 and Phys. 2D; or Chem. 6C, Math. 20D or 21D, Math. 20F,
and Phys. 2AB; or consent of instructor. (S)
134. Computer Programming in Chemistry (4) Use
of computer programming in the analysis and presentation of chemical
data (statistical analysis, least squares fitting procedures, titration
curve interpretation, analysis of radioactive decay series, chemical
kinetics, organic synthesis, etc.) Prerequisites: Math. 20A and
20B or equivalent. (Note: Students may not receive credit for
both Chem. 134 and BIBC 115.) (May not be offered every year.)
135. Molecular Spectroscopy (4) Time-dependent
behavior of systems; interaction of matter with light; selection
rule. Radiative and nonradiative processes, coherent phenomena,
and the density matrices. Instrumentation, measurement, and interpretation.
Prerequisites: Chem. 133 or equivalent; Math. 20D or 21D, or
Chem. 190/290. (May not be offered every year.)
140A. Organic Chemistry I (4) Introduction
to organic chemistry, with applications to biochemistry. Bonding
theory, isomerism, stereochemistry, chemical and physical properties.
Introduction to substitution, addition, and elimination reactions.
Students may not receive credit for both Chem. 140A and Chem. 141A.
Prerequisite: Chem. 6C or equivalent course in general chemistry.
(F,W,S)
140B. Organic Chemistry II (4) Continuation
of Organic Chemistry I, 140A. Methods of analysis, chemistry of
hydrocarbons, chemistry of the carbonyl group. Introduction to the
reactions of biologically important molecules. Students may not
receive credit for both Chem. 141B and Chem. 140B. Prerequisite:
Chem. 140A (a grade of C or higher in Chem. 140A is strongly recommended).
(F,W,S)
140C. Organic Chemistry III (4) Continuation
of Organic Chemistry I (140A) and Organic Chemistry II (140B). Organic
chemistry of biologically important molecules: carboxylic acids,
carbohydrates, proteins, fatty acids, biopolymers, natural products.
Students may not receive credit for both Chem. 140C and Chem. 141C.
Prerequisite: Chem. 140B (a grade of C or higher in Chem. 140B is
strongly recommended). (F,W,S)
141A. Organic Chemistry (4) Chem. 141A
introduces theoretical and experimental studies of structure and
properties of covalent molecules. Both resonance and simple molecular
orbital descriptions of organic compounds are introduced and spectroscopic
methods for determining electronic and molecular structure are discussed.
Organic reactions are introduced with synthetic and mechanistic
examples. Prerequisites: Chem. 6C (6C may be taken concurrently
by good students). Prior or concurrent physics recommended.
(Note: Students may not receive credit for both Chem. 141A and Chem.
140A.) (F)
141B. Organic Chemistry (4) A continuation
of Chem. 141A, this course applies the structure-reactivity, spectroscopy,
and electronic theories introduced in Chem. 141A to organic reactions.
Prerequisite: Chem. 141A or consent of instructor. (Note:
Students may not receive credit for both Chem. 141B and Chem. 140B.)
(W)
141C. Organic Chemistry (4) A continuation
of 141A-B, this course treats selected topics such as carbon-metal
bonds, organometallic chemistry, electrophilic reactions, free radical
reactions, alkane chemistry, polymerization, molecular orbital theory
and electrocyclic reactions, photochemistry, unstable intermediates
such as carbenes, benzyne, etc., and metal oxidation reactions,
and an introduction to carbohydrate and protein chemistry. Prerequisite:
Chem. 141B or consent of instructor. (Note:
Students may not receive credit for both Chem. 141C and Chem. 140C.)
(S)
143A. Organic Chemistry Laboratory (4) Introduction
to laboratory techniques needed in organic chemistry. Stresses physical
methods including separation and purification, spectroscopy, product
analysis and effects of reaction conditions. Prerequisites: Chem.
6BL and Chem. 140A or Chem. 141A. (Note: Students may not receive
credit for both Chem. 143A and Chem. 143AM.) A materials fee is
required for this course. (F,W,S)
143AM. Advanced Organic Chemistry Laboratory (4) An
organic chemistry laboratory intended for chemistry majors only.
It is similar to Chem. 143A, but with emphasis on instrumental methods
of product identification, separation, and analysis. Prerequisites:
Chem. 6BL, Chem. 140A or Chem. 141A. (Note: Students may not
receive credit for both Chem. 143AM and Chem. 143A.) This course
is restricted to majors only. A materials fee is required for this
course. (W)
143B. Organic Chemistry Laboratory (4) Continuation
of Chem. 143AM or 143A, emphasizing synthetic methods of organic
chemistry. Prerequisites: Chem. 143AM or 143A, Chem. 140B (may
be taken concurrently). Enrollment is limited to majors in
the Department of Chemistry and Biochemistry, unless space is available.
A materials fee is required for this course. (W,S)
143C. Organic Chemistry Laboratory (5) Identification
of unknown organic compounds by a combination of chemical and physical
techniques. This course is intended for chemistry majors only. Prerequisites:
Chem. 6CL and 143 AM or 143A or equivalent (may be taken concurrently);
143B recommended. A materials fee is required for this course.
(F)
143D. Molecular Design and Synthesis (4)
Advanced organic synthesis. Relationships between
molecular structure and reactivity using modern synthetic methods
and advanced instrumentation. Stresses importance of molecular design,
optimized reaction conditions for development of practically useful
synthesis, and problem-solving skills. Prerequisites: Chem.
140C and Chem. 143B. A materials fee is required for this course.
(S)
149A. Environmental Chemistry (4) The
chemical basis of air and water pollution, chlorofluorocarbons and
the ozone hole, the environmental impact of radioactive waste disposal,
mineral resource usage, and nuclear energy. Prerequisites: Chem.
6C or 6CH or equivalent. (F)
149B. Environmental Chemistry (4) Agricultural
productivity, biological impact on the environment, deforestation,
environmental disasters (fires, nuclear winter, and volcanoes),
and organic waste handling. Prerequisite: Chem. 149A. (W)
152. Synthetic Methods in Organic Chemistry (4) (Formerly
Chem. 148) A survey of reactions of particular utility in the organic
laboratory. Emphasis is on methods of preparation of carbon-carbon
bonds and oxidation reduction sequences. Prerequisites: Chem.
140C or Chem. 141C or consent of instructor.
154. Mechanisms of Organic Reactions (4) (Formerly
Chem. 147) A qualitative approach to the mechanisms of various organic
reactions; substitutions, additions, eliminations, condensations,
rearrangements, oxidations, reductions, free-radical reactions,
and photochemistry. Includes considerations of molecular structure
and reactivity, synthetic methods, spectroscopic tools, and stereochemistry.
The topics emphasized will vary from year to year. This is the first
quarter of the advanced organic chemistry sequence. Prerequisites:
Chem. 140C or 141C.
155. Synthesis of Complex Molecules (4) (Formerly
Chem. 144) This course discusses planning economic routes for the
synthesis of complex organic molecules. The uses of specific reagents
and protecting groups will be outlined as well as the control of
stereochemistry during a synthesis. Examples will be selected from
the recent literature. (May not be offered every year.) Prerequisites:
Chem. 152 or 252 or consent of instructor.
156. Structure and Properties of Organic Molecules (4) (Formerly
Chem. 145) Introduction to the measurement and theoretical correlation
of the physical properties of organic molecules. Topics covered
include molecular geometry, molecular-orbital theory, orbital hybridization,
aromaticity, chemical reactivity, stereochemistry, infrared and
electronic spectra, photochemistry, and nuclear magnetic resonance.
Prerequisites: Chem. 140ABC or 141ABC or the equivalent.
157. Bioorganic and Natural Products Chemistry (4) (Formerly
Chem. 142) A comprehensive survey of modern bioorganic and natural
products chemistry. Topics will include biosynthesis of natural
products, molecular recognition, and small molecule-biomolecule
interactions. Prerequisites: Chem. 140C or 141C or 254 or consent
of the instructor.
161. Supramolecular Coordination Chemistry (4) An
introduction and survey of modern coordination chemistry. Topics
will include structure and bonding of alkali, transition, lanthanide
and actinide metals, with emphasis on the first row transition metals;
stereochemistry, coordination clusters, molecular solids and nanoparticles.
Prerequisites: Chem. 120A and 120B or equivalent.
166. Environmental and Molecular Toxicology Molecular
and cellular mechanisms underlie the actions of environmental toxicants.
This course will investigate approaches to study the impact of environmental
toxicants on human health. Other modern approaches that are being
implemented to detect and remediate environmental toxicants will
also be examined. Prerequisites: Chem. 114A-B.
168. Bioenergetics (4) Chemiosmotic processes
in mitochondria and photosynthetic organelles, structure-function
relationships of membrane protein apoptosis, a refined view of mitochondrial
structure deduced from electron tomography, and the role of proteins
encoded by mitochondrial DNA in oxidative phosphorylation. Prerequisites:
Chem. 114 A and Chem. 114B (or equivalents.)
170. Cosmochemistry (4) Composition of
stars, of planets, of meteorites, and the earth. Nuclear stability
rules and isotopic composition of the elements. Chemical properties
of solar matter. Origin of the elements and of the solar system
Prerequisite: general chemistry sequence.
171. Nuclear and Radiochemistry (4) Radioactive
decay, stability systematics, neutron activation, nuclear reactions.
Szilard-Chalmers reactions, hot-atom chemistry, radiation chemistry,
effects of ionizing radiation. Prerequisite: general chemistry
sequence.
173. Atmospheric Chemistry (4) Chemical
principles applied to the study of atmospheres. Atmospheric photochemistry,
radical reactions, chemical lifetime determinations, acid rain,
greenhouse effects, ozone cycle, and evolution are discussed. Prerequisites:
Chem. 6A-6C or 6AH, 6BH, and 6 CH, or quivalent. (S)
182. Biological Databases (4)
This course provides an introduction to the features of biological
data, how those data are organized efficiently in databases, and
how existing data resources can be utilized to solve a variety of
biological problems. Object oriented databases, data modeling, and
description. Survey of current biological database with respect
to above, implementation of database on a biological topic. Prerequisite:
CSE 100 or Math. 176. Bioinformatics majors only.
184. Computational Molecular Biology (4)
This advanced course covers the application of machine learning
and modeling techniques to biological systems. Topics include gene
structure, recognition of DNA and protein sequence patterns, classification,
and protein structure prediction. Pattern discovery, Kidden Markov
models/support vector machines/neural network/profiles, protein
structure prediction, functional characterization or proteins, functional
genomics/proteomics, metabolic pathways/gene networks. Prerequisites:
BIMM 181 or BENG 181 or CSE 181; BIMM 182 or BENG 182 or CSE 182
or CHEM 182. Bioinformatics majors only.
185. Introduction to Computational Chemistry (4) Course
in computational methods building on a background in mathematics
and physical chemistry. Brief introduction and background in computational
theory, molecular mechanics, semi-empirical methods, and ab initio-based
methods of increasing elaboration. Emphasis on applications and
reliability. Prerequisites: Chem. 126 or 133 and Math. 20C or
21C. (May not be offered every year.)
190. Mathematical Methods in Chemistry I (4) Applied
mathematics useful in kinetics, spectroscopy, thermodynamics, statistical
mechanics and quantum mechanics; ordinary and partial differential
equations, vector spaces, operators, linear algebra, numerical analysis.
Prerequisites: general chemistry, calculus. (May not be
offered every year.)
195. Methods of Teaching Chemistry (4) An
introduction to teaching chemistry. Students are required to attend
a weekly class on methods of teaching chemistry, and will teach
a discussion section of one of the lower-division chemistry courses.
Attendance at lecture of the lower-division course in which the
student is participating is required. (P/NP grades only.) Prerequisite:
consent of instructor. (F,W,S)
196. Reading and Research in Chemical Education (2 or 4)
Independent literature or classroom research by
arrangement with, and under the direction of, a member of the Department
of Chemistry and Biochemistry faculty. Students must register on
a P/NP basis. Prerequisites: upper-division standing, 2.5 minimum
GPA, consent of instructor and department.(F,W,S)
199. Reading and Research (2 or 4) Independent
literature or laboratory research by arrangement with, and under
the direction of, a member of the Department of Chemistry and Biochemistry
faculty. Students must register on a P/NP basis. Prerequisites:
upper-division standing, 2.5 minimum GPA, consent of instructor
and department. (F,W,S)
Graduate
207. Modern NMR Methods (4) Treats varied
pulse sequences, one- and two-dimensional methods, interpretation
of relaxation rates, spin-decoupling, multiple quantum filtering,
and solvent suppression with application to liquid crystals, membranes,
small molecules, proteins, and nucleic acids. Prerequisite:
does not require extensive mathematics, but Chem. 130 recommended.
(May not be offered every year.)
209. Macromolecular Recognition (4) Structures
and functions of nucleic acids, folding and catalysis of nucleic
acids, motifs and domains of proteins, principles of protein-protein
interactions, chemistry of protein/DNA and protein/RNA interfaces,
conformational changes in macromolecular recognition. Prerequisites:
biochemistry background and graduate standing, or approval of instructor.
211. Metabolic Biochemistry (4) A comprehensive
course in biochemistry emphasizing metabolic and human biochemistry.
Prerequisites: physical and organic chemistry; graduate standing.
(F)
213. Chemistry of Biological Macromolecules (4) A
discussion of the structural principles governing biological macromolecules,
the techniques used in their study, and how their functional properties
depend on three-dimensional structure. Chem. 213 students will be
required to complete additional coursework beyond that expected
of students in Chem. 113. Prerequisites: elementary physical
and organic chemistry. (May not be offered every year.)
214. Molecular and Cellular Biochemistry (4) This
course represents a continuation of 114C, or an introductory course
for first- and second-year graduate students, and covers topics
in molecular and cellular biochemistry. Emphasis will be placed
on contemporary approaches to the isolation and characterization
of mammalian genes and proteins, and molecular genetic approaches
to understanding eukaryotic development and human disease. Chem.
214 students will be required to complete additional coursework
beyond that expected of students in Chem. 114D. Prerequisite:
Chem. 114A-C or consent of instructor. (May not be offered every
year.)
215. Modeling Biological Macromolecules (4) Use
of computer graphics and modeling methods in the study of biological
macromolecules. The course will cover basic methods and techniques.
The objective is to provide a good working knowledge of the critical
features of the methods and to provide a foundation for further
study for those who wish to pursue these methods as research topics.
Chem. 215 students will be required to complete additional coursework
beyond that expected of students in Chem. 115. Prerequisite:
Chem. 114A or equivalent. (May not be offered every year.)
216. Chemistry of Enzyme Catalyzed Reactions (4) A
discussion of the chemistry of representative enzyme catalyzed reactions
is presented. Enzyme reaction mechanisms and their relation to enzyme
structure are emphasized. Chem. 216 students will be required to
complete additional coursework beyond that expected of students
in Chem. 116. Prerequisites: Chem. 140A-B-C, 114A and 126 or
131. (May not be offered every year.)
218. Macromolecular Biochemistry (4) A
comprehensive course in biochemistry emphasizing structural biochemistry.
Prerequisites: physical and organic chemistry; graduate-student
standing. (F)
219A-B-C. Special Topics in Biochemistry (4-4-4) This
special topics course is designed for first-year graduate students
in biochemistry. Topics presented in recent years have included
protein processing, the chemical modification of proteins, the biosynthesis
and function of glycoproteins, lipid biochemistry and membrane structure,
and bioenergetics. Prerequisites: undergraduate courses in biochemistry.
Chem. 114A or equivalent. (May not be offered every year.)
221. Signal Transduction (4) The aim of
this course is to develop an appreciation for a variety of topics
in signal transduction. We will discuss several historical developments
while the focus will be on current issues. Both experimental approaches
and results will be included in our discussions. Topics may vary
from year to year. Prerequisites: biochemistry and molecular
biology. (May not be offered every year.)
222. Structure and Analysis of Solids (4) Key
concepts in the atomic structure and bonding of solids such as metals,
ceramics, and semiconductors. Symmetry operations, point groups,
lattice types, space groups, simple and complex inorganic compounds,
structure/property comparisons, structure determination with X-ray
diffraction. Ionic, covalent, metallic bonding compared with physical
properties. Atomic and molecular orbitals, bands versus bonds, free
electron theory.
223. Organometallic Chemistry (4) A survey
of this field from a synthetic and mechanistic viewpoint. Reactivity
patterns for both main group and transition element organometallic
compounds will be discussed and organized according to periodic
trends. (May not be offered every year.)
224. Spectroscopic Techniques (4) Application
of physical techniques to the elucidation of the structure of inorganic
complex ions and organometallic compounds. Topics covered include
group theory, and its application to vibrational, magnetic resonance
and Raman spectroscopy. (May not be offered every year.)
225. Bioinorganic Chemistry (4) The role
of metal ions in biological systems, with emphasis on transition
metal ions in enzymes that transfer electrons, bind oxygen, and
fix nitrogen. Also included are metal complexes in medicine, toxicity,
and metal ion storage and transport. Chem. 225 students will be
required to complete an additional paper and/or exam beyond that
expected of students in Chem. 124. Prerequisites: Chem. 6C or
6CH. Chem. 114A and 120A recommended. (May not be offered every
year.)
227. Seminar in Inorganic Chemistry (2) Seminars
presented by faculty and students on topics of current interest
in inorganic chemistry, including areas such as bioinorganic, organometallic
and physical-inorganic chemistry. The course is designed to promote
a critical evaluation of the available data in specialized areas
of inorganic chemistry. Each quarter three or four different topics
will be discussed. Prerequisite: graduate standing or consent
of instructor. (S/U grades only.)
228. Solid State Chemistry (4) Survey
of the chemistry of semiconductors, superconductors, molecular magnetic
materials, zeolites, fast ion conductors, electronically conducting
polymers and ceramics. Synethetic techniques such as molecular precursor
design, the sol-gel process, electrosynthesis, and high-temperature
thermolysis will be covered. (May not be offered every year.)
229. Special Topics in Inorganic Chemistry (2-4) Selection
of topics of current interest. May be repeated for credit when topics
vary. (May not be offered every year.)
230. Quantum Mechanics (4) Concepts and
mathematical formalism that are useful for problems of chemical
interest: states, representations, operators, eigenvalues and eigenfunctions,
time evolution, observables, and measurements. Time- independent
perturbation theory. Prerequisites: Chem. 133 or equivalent;
Math. 20D or equivalent; Chem. 190 may be taken concurrently.
(May not be offered every year.)
231. Chemical Kinetics and Molecular Reaction Dynamics (4)
Classical kinetics, transition state theory, unimolecular decomposition,
potential energy surfaces; scattering processes and photodissociation
processes. Prerequisite: Chem. 230. (May not be offered ever
year.)
232. Statistical Mechanics of Chemical Systems (4)
Equilibrium statistical mechanics, distribution functions, and partition
functions. Boltzman, Bose, and Fermi statistics. The different ensembles;
ensemble averages and QM expectation values; derivation of thermodynamic
properties of simple systems. Prerequisites: Chem. 131, 132 and
133, or equivalent. (May not be offered every year.)
235. Molecular Spectroscopy (4) Time-dependent
behavior of systems; interaction of matter with light; selection
rule. Radiative and nonradiative processes, coherent phenomena and
the density matrices. Instrumentation, measurement, and interpretation.
Chem. 235 students will be required to complete additional coursework
beyond that expected of students in Chem. 135. Prerequisites:
Chem. 133 or equivalent; Math. 20D or 21D; or Chem. 190/290.
(May not be offered every year.)
236. Atherosclerosis (2 or 4) Multidisciplinary
course integrating topics concerning the pathogenesis of arteriosclerosis,
with emphasis on cholesterol and lipoprotein metabolism, and the
cellular and biochemical mechanisms of lesion development. Topics
include relationship of coronary heart disease to hyperlipoproteinemias,
management of risk factors, and therapeutic approaches. Two-hour
lectures. Same as Medicine 236. Prerequisite: biochemistry. (May
not be offered every year.)
237. Essentials of Glycobiology (4) Advanced
elective for graduate/medical students who have had core courses
in cell biology or biochemistry. Expert faculty will present a coordinated
overview of the field of glycobiology, which explores the structure,
synthesis, and functions of sugar chains in biological systems.
(May not be offered every year.)
239. Special Topics in Chemical Physics (2-4)
Topics of special interest will be presented. Examples include NMR,
solid-state chemistry, phase transitions, stochastic processes,
scattering theory, nonequilibrium processes, tensor transformations,
and advanced topics in statistical mechanics, thermodynamics, and
chemical kinetics. (May not be offered every year.)
240. Electrochemistry (4) Application
of electrochemical techniques to chemistry research. Basic electrochemical
theory and instrumentation: the diffusion equations, controlled
potential, and current methods. Electro-chemical kinetics, Butler-Volmer,
Marcus-Hush theories, preparative electrochemistry, analytical electrochemistry,
solid and polymer electrolytes, semiconductor photoelectrochemistry.
(May not be offered every year.)
246. Kinetics and Mechanism (4) Methodology
of mechanistic organic chemistry: integration of rate expressions,
determination of rate constants, transition state theory; catalysis,
kinetic orders, isotope effects, substituent effects, solvent effects,
linear free energy relationship; product studies, stereochemistry;
reactive intermediates; rapid reactions. (May not be offered every
year.)
250. Seminar in Chemistry (2) Regularly
scheduled seminars by first-year graduate students provide opportunities
for practice in seminar delivery and for the exploration of topics
of general interest. (S/U grades only.) (S)
251. Research Conference (2) Group discussion
of research activities and progress of the group members. Prerequisite:
consent of instructor. (S/U grades only.) (F,W,S)
252. Synthetic Methods in Organic Chemistry (4)
(Formerly Chem. 248) A survey of reactions of particular utility
in the organic laboratory. Emphasis is on methods of preparation
of carbon-carbon bonds and oxidation reduction sequences. Chem.
252 students will be required to complete additional coursework
beyond that expected of students in Chem. 152. Prerequisite:
Chem. 140C or 141C or consent of instructor.
254. Mechanisms of Organic Reactions (4)
(Formerly Chem. 247) A qualitative approach to the mechanisms of
various organic reactions; substitutions, additions, eliminations,
condensations, rearrangements, oxidations, reductions, free-radical
reactions, and photochemistry. Includes considerations of molecular
structure and reactivity, synthetic methods, spectroscopic tools,
and stereochemistry. The topics emphasized will vary from year to
year. This is the first quarter of the advanced organic chemistry
sequence. Chem. 254 students will be required to complete an additional
paper and/or exam beyond that expected of students in Chem. 154.
Prerequisites: Chem. 140C or Chem. 141C or graduate standing.
255. Synthesis of Complex Molecules (4)
(Formerly Chem. 244) This course discusses planning economic routes
for the synthesis of complex organic molecules. The uses of specific
reagents and protecting groups will be outlined as well as the control
of stereochemistry during a synthesis. Examples will be selected
from the recent literature. Chem. 255 students will be required
to complete an additional paper and/or exam beyond that expected
of students in Chem. 155. (May not be offered every year.) Prerequisites:
Chem. 152 or 252 or consent of instructor.
256. Structure and Properties of Organic Molecules (4)
(Formerly Chem. 245) Introduction to the measurement and theoretical
correlation of the physical properties of organic molecules. Topics
covered include molecular geometry, molecular-orbital theory, orbital
hybridization, aromaticity, chemical reactivity, stereochemistry,
infrared and electronic spectra, photochemistry, and nuclear magnetic
resonance. Chem. 256 students will be required to complete an additional
paper and/or exam beyond that expected of students in Chem. 156.
Prerequisites: Chem. 140ABC or 141ABC or the equivalent.
257. Biorganic and Natural Products Chemistry (4)
(Formerly Chem. 242) A comprehensive survey of modern bioorganic
and natural products chemistry. Topics include biosynthesis of natural
products, molecular recognition, and small molecule-biomolecule
interactions. Chem. 257 students will be required to complete additional
coursework beyond that expected of students in Chem. 157. Prerequisites:
Chem. 140C, 141C, 254 or consent of instructor.
258. Applied Spectroscopy (4) Intensive
coverage of modern spectroscopic techniques used to determine the
structure of organic molecules. Problem solving and interpretation
of spectra will be strongly emphasized. Prerequisites: Chem.
254 or consent of instructor.
259. Special Topics in Organic Chemistry (2-4)
(Formerly Chem. 249) Various advanced topics in organic chemistry.
Includes but is not limited to: advanced kinetics, advanced spectroscopy,
computational chemistry, heterocyclic chemistry, medicinal chemistry,
organotransition metal chemistry, polymers, solid-phase synthesis/combinatorial
chemistry, stereochemistry, and total synthesis classics.
261. Supramolecular Coordination Chemistry (4) An
introduction and survey of modern coordination chemistry. Topics
will include structure and bonding of alkali, transition, lanthanide,
and actinide metals, with emphasis on the first row transition metals;
stereochemistry, coordination clusters, molecular solids and nanoparticles.
Chem. 261 students will be required to complete additional coursework
beyond that expected of students in Chem. 161. Prerequisites:
Chem. 120A, 120B or equivalent; or graduate standing.
262. Inorganic Chemistry and NMR (4) A
survey of inorganic chemistry to prepare for graduate research in
the field, including a detailed introduction to nuclear magnetic
resonance (NMR), followed by applications of NMR to structural and
mechanistic problems in inorganic chemistry.
266. Environmental and Molecular Toxicology
Molecular and cellular mechanisms underlie the actions of environmental
toxicants. This course will investigate approaches to study the
impact of environmental toxicants on human health. Other modern
approaches that are being implemented to detect and remediate environmental
toxicants will also be examined.
268. Bioenergetics (4) Chemiosmotic processes
in mitochondria and photosynthetic organelles, structure-function
relationships of membrane protein apoptosis, a refined view of mitochondrial
structure deduced from electron tomography and the role of proteins
encoded by mitochondrial DNA in oxidative phosphorylation. Chem.
268 students will be required to complete additional coursework
beyond that expected of students in Chem. 168. Prerequisites:
Chem. 114 A and Chem. 114B (or equivalents.)
270A-B-C. Current Topics in Environmental Chemistry (2-2-2)
Seminar series on the current topics in the field of environmental
chemistry. Emphasis is on current research topics in atmospheric,
oceanic, and geological environments. Prerequisite: consent of
instructor. (S/U grades only.) (May not be offered every year.)
273. Atmospheric Chemistry Chemical
principles applied to the study of atmospheres. Atmospheric photochemistry,
radical reactions, chemical lifetime determinations, acid rain,
greenhouse effects, ozone cycle, and evolution are discussed. Chem.
273 students will be required to complete additional coursework
beyond that expected of students in Chem. 173. Prerequisites:
Chem. 6A-B-C, or Chem. 6AH, 6BH and 6CH, or equivalent, or graduate
standing. (S)
285. Introduction to Computational Chemistry (4)
Course in computational methods building on a background in mathematics
and physical chemistry. Brief introduction and background in computational
theory, molecular mechanics, semi-empirical methods, and ab initio-based
methods of increasing elaboration. Emphasis on applications and
reliability. Chem. 285 students will be required to complete an
additional paper and/or exam beyond that expected of students in
Chem. 185. Prerequisites: Chem. 126 or 133 and Math. 20C.
(May not be offered every year.)
290. Mathematical Methods in Chemistry (4)
Applied mathematics useful in kinetics, spectroscopy, thermodynamics,
statistical mechanics, and quantum mechanics; ordinary and partial
differential equations, vector spaces, operators, linear algebra,
numerical analysis. Chem. 290 students will be required to complete
additional coursework beyond that expected of students in Chem.
190. Prerequisites: general chemistry, calculus. (May not
be offered every year.)
293. Cosmochemistry Seminar (2) Formal
seminars or informal sessions on topics of current interest in cosmochemistry
as presented by visiting lecturers, local researchers, or students.
Prerequisite: advanced graduate-student standing. (S/U grades
only.)
294. Organic Chemistry Seminar (2) Formal
seminars or informal puzzle sessions on topics of current interest
in organic chemistry, as presented by visiting lecturers, local
researchers, or students. Prerequisite: advanced graduate-student
standing. (S/U grades only.) (F,W,S)
295. Biochemistry Seminar (2) Formal seminars
or informal puzzle sessions on topics of current interest in biochemistry,
as presented by visiting lecturers, local researchers, or students.
Prerequisite: advanced graduate-student standing. (S/U grades
only.)
296. Chemical Physics Seminar (2) Formal
seminars or informal sessions on topics of current interest in chemical
physics as presented by visiting lecturers, local researchers, or
students. Prerequisite: advanced graduate-student standing.
(S/U grades only.) (F,W,S)
297. Experimental Methods in Chemistry (4)
Experimental methods and techniques involved in chemical research
are introduced. Hands-on experience provides training for careers
in industrial research and for future thesis research. Prerequisite:
graduate standing.
298. Special Study in Chemistry (1-4)
Reading and laboratory study of special topics for first-year graduate
students under the direction of a faculty member. Exact subject
matter to be arranged in individual cases. (S/U grades only.) Prerequisite:
first-year graduate student standing. (F,W,S)
299. Research in Chemistry (1-12) Prerequisites:
graduate standing and consent of instructor. (S/U grades only.)
(F,W,S)
500. Teaching in Chemistry (4) A doctoral
student in chemistry is required to assist in teaching undergraduate
chemistry courses. One meeting per week with instructor, one or
more meetings per week with assigned class sections or laboratories,
and attendance at the lecture of the undergraduate course in which
he or she is participating. Prerequisites: graduate standing
and consent of instructor. (S/U grades only.) (F,W,S)
Chemistry and Biochemistry Courses
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