 |
 |
 |
 |
 |
CoursesNote: The department will endeavor to offer the courses as outlined below; however, unforeseen circumstances sometimes mandate a change of scheduled offerings. Students are strongly advised to check with the department’s Student Affairs Office. This is of particular importance in planning schedules for graduation requirements. The following schedule is tentative for the academic year 2004–2005 only. It should not be assumed that the same schedule will continue after this academic year. It is the student’s responsibility to contact the Student Affairs Office to determine the specific quarter that courses will be offered. Prerequisites are enforced when adding courses. Students who have satisfied Prerequisites at another institution or by AP credit need to be pre-authorized to register in these courses. Please contact the Student Affairs Office before your scheduled registration time to be pre-authorized. Lower-Division1. Introduction to Bioengineering (1) An introduction to the central topics of bioengineering in a seminar format. The principles of problem definition, team design, engineering inventiveness, information access, communication, ethics, and social responsibility will be emphasized. P/NP grading only. Prerequisite: none. (W) 87. Freshman Seminar (1) The Freshman Seminar Program is designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small seminar setting. Freshman seminars are offered in all campus departments and undergraduate colleges, and topics vary from quarter to quarter. Enrollment is limited to fifteen to twenty students, with preference given to entering freshmen. (F,W,S) 90. Undergraduate Seminar (1) Selected topics of interest to the faculty will be used to introduce students to bioengineering science and design concepts. (Not open to upper-division bioengineering students.) (F,W,S) 97. Internship/Field Studies (1-4) An enrichment program available to a limited number of lower-division undergraduate students, which provides work experience with industry, government offices, and hospitals. The internship is coordinated through UCSD’s Academic Internship Program under the supervision of a faculty member and an industrial, government, or hospital employee. Prerequisites: lower-division standing, completion of thirty units of UCSD undergraduate study, a minimum UCSD GPA of 3.0, and a completed and approved ”Special Studies” form, “UCSD Application for Enrollment Special Studies Courses 97, 98, 99.” (F,W,S) 98. Directed Group Study (1-4) Directed group study on a topic or in a field not included in the regular department curriculum. (P/NP grades only.) Prerequisites: lower-division standing, completion of thirty units of undergraduate study at UCSD with a UCSD GPA of at least 3.0 and consent of a Bioengineering faculty member; completed and approved Special Studies form. 99. Independent Study for Undergraduates (4) Independent reading or research by arrangement with a Bioengineering faculty member. (P/NP grades only.) Prerequisites: lower-division standing, completion of thirty units of undergraduate study at UCSD with a UCSD GPA of at least 3.0 and consent of a bioengineering faculty member; completed and approved Special Studies form. Upper-Division100. Introduction to Bioengineering Design (4) A general introduction to bioengineering design, including examples of engineering analysis and design applied to representative topics in biomechanics, bioinstrumentation, biomaterials, biotechnology, and related areas. A review of technological needs, design methodology, testing procedures, statistical analysis, governmental regulation, evaluation of costs and benefits, quality of life, and ethical issues. Prerequisites: BENG 1; grade of C– or better in Math. 21C or Math. 20C and Math. 21D or Math. 20D, and Physics 2C; majors only. (S) 101. Foundations of Biomedical Imaging (4) An introduction to the principles and applications of biomedical imaging, with emphasis on the acquisition, processing, display of imagery, and design of imaging systems. Filtering, convolution, and Fourier methods. Microscopy, radiography, computed tomography, magnetic resonance, ultrasound, and nuclear imaging. Prerequisites: Grade of C- or better in BENG 100; majors only or consent of department. (F) 103B. Bioengineering Mass Transfer (4) Mass transfer in solids, liquids, and gases with application to biological systems. Free and facilitated diffusion. Convective mass transfer. Diffusion-reaction phenomena. Active transport. Biological mass transfer coefficients. Steady and unsteady state. Flux-force relationships. (Students may not receive credit for both CENG 101C and BENG 103B.) Prerequisites: grade of C– or better in BENG 112A; majors only. (S) 106B. Bioengineering Dynamics (4) Kinematics and kinetics of particles and rigid bodies. Muscle and joint loads. Musculoskeletal dynamics, locomotion, and clinical applications. Bodies in contact: friction, momentum, and impulse; impact and injury. Work, power, and energy relationships; conservation laws of dynamics. Bioengineering design problems, problem formulation, and problem solutions. (Students may receive credit for one of the following: MAE 130B, SE 101B, or BENG 106B.) Prerequisites: grade of C– or better in Math. 21D or Math 20D and MAE 130A/SE 101A; majors only. (W) 110. Continuum Mechanics (4) An introduction to continuum mechanics of both living and non living bodies. The laws of motion and free-body diagrams. Stresses. Deformation. Compatibility conditions. Constitutive equations. Properties of common fluids and solids. Derivation of field equations and boundary conditions. Applications to bioengineering design. Prerequisites: grades of C– or better in Physics 2A, 2B, 2C; majors only. (F) 112A. Biomechanics (4) Introduction to physiological systems, with emphasis on structure and function of major tissues and organs. Application of mechanics to understand the behavior of these tissues and organs at gross and microscopic levels. Bioelastic solids. Rigid body biomechanics. Biofluids. Bioengineering and medical design. Prerequisites: grade of C– or better in BENG 110; majors only. (W) 112B. Biomechanics (4) Biomechanics of living tissues with emphasis on continuum analysis of problems in biofluid and cell mechanics. Engineering design and problem solving in the biomechanics of mammalian tissues, especially those of the cardiovascular system. Prerequisites: grade of C– or better in BENG 112A; majors only. (S) 122A. Biosystems and Control (4) Systems and control theory applied to bioengineering. Modeling, linearization, transfer functions, Laplace transforms, closed-loop systems, design and simulation of controllers. Dynamic behavior and controls of first and second order processes. PID controllers. Stability. Bode design. Features of biological controls systems. A simulation term project using MATLAB and an oral presentation are required. Prerequisites: grade of C– or better in MAE 140; majors only or consent of department. (W) 122B. Biomedical Electronics (4) Analog and digital circuits in bioinstrumentation. Biomedical signals in continuous and discrete systems. Sampling and digital signal processing. MRI. CT. Ultrasound. Bioelectromagnetics. Electrokinetics. Prerequisites: grade of C– or better in BENG 122A and BENG 186B; majors only or permission of instructor. (S) 123. Systems Biology and Bioengineering (4) Systems biology and bioengineering is comprised of (1) enumeration of biological components participating in a biological process, (2) reconstruction of interactions to form a network, (3) mathematical representation for analysis, interpretation, and prediction, (4) model validation and use in prospective design. Prerequisites: grade of C– or better in BIBC 100; majors only. (W) 125. Modeling and Computation in Bioengineering (4) Computational modeling of molecular bioengineering phenomena: excitable cells, regulatory networks, and transport. Application of ordinary, stochastic, and partial differential equations. Introduction to data analysis techniques: power spectra, wavelets, and nonlinear time series analysis. Prerequisites: grade of C– or better in BENG 122A or BENG 123; majors only or consent of instructor. (S) 130. Molecular Physical Chemistry (4) An introduction to physical principles that govern biological matter and processes. Thermodynamic principles and their molecular origin, structural basis of life and physical and conceptual models to illustrate life phenomena. (Students may receive credit for one of the following: Chem. 126, Chem. 127, Chem. 131, or BENG 130.) Prerequisites: grade of C– or better in Chem 6B, Math. 20A, 20B, Physics 2A, 2B, 2C. (Physics 2C may be taken concurrently.); majors only. (W) 140A. Bioengineering Physiology (4) Introductory mammalian physiology for bioengineering students, with emphasis on control mechanisms and engineering principles. Basic cell functions; biological control systems; muscle; neural; endocrine, and circulatory systems. Not intended for premedical bioengineering students. (Students may not receive credit for both BIPN 100 and BENG 140A.) Prerequisites: grade of C– or better in Chem. 6A, 6B, Physics 2A, 2B, 2C, BILD 1; majors only. (W) 140B. Bioengineering Physiology (4) Introductory mammalian physiology for bioengineering students, with emphasis on control mechanisms and engineering principles. Digestive, respiratory, renal, and reproductive systems; regulation of metabolism, and defense mechanisms. (Students may not receive credit for both BIPN 102 and BENG 140B.) Prerequisite: grade of C– or better in BENG 140A; majors only. 161A. Bioreactor Engineering (4) Introduction to the principles and practices of biochemical engineering. Important engineering, biochemical and physiological considerations in the design of bioreactor processes: enzyme kinetics, mass transfer limitations, microbial growth, and product formation kinetics. Fermentation reactor selection, design, scale-up, and control. Prerequisites: grade of C– or better in Chem 114B or BIBC 102 (may be taken concurrently), BENG 122A and admission to the major. (F) 161B. Biochemical Engineering (4) Commercial production of biochemical commodity products. Application of genetic control systems and mutant populations. Recombinant DNA and eucaryotic proteins in E. coli and other host organisms. Product recovery operations, including the design of bioseparation processes of filtration, adsorption, chromatography, and crystallization. Bioprocess economics. Human recombinant erythropoietin as an example, from genomic cloning to CHO cell expression, to bioreactor manufacturing and purification of medical products for clinical application. Prerequisite: grade of C– or better in BENG 161A; majors only. (W) 161C. Metabolic Engineering (4) Engineering systems analysis of metabolic and regulatory processes. Use of high-throughput data for network reconstruction. Formulation of the stoichiometric matrix and its uses to determine steady state flux distributions. Kinetics of individual enzymatic reactions. Computer simulations of metabolic networks, systemic sensitivity coefficients, bifurcations to study dynamic network functions. Temporal decomposition of metabolic processes into multiple time scales and the physiologic roles of metabolic events in each scale. Prerequisite: grade of C– or better in BENG 161B; majors only. (S) 162. Biotechnology Laboratory (4) Laboratory practices and design principles for biotechnology. Culture of microorganisms and mammalian cells, recombinant DNA bioreactor design and operation. Design and implementation of biosensors. A team design-based term project and oral presentation required. Prerequisites: admission to the major; MAE 170, BENG 166A, BENG 161B (must be taken concurrently). (W) 164. Bioengineering of Biochemical Techniques (1) Quantitative bioengineering analysis and design of biochemical processes and experiments on biological molecules. Centrifugation, electrophoresis, chromatography. Radioactive tracers. Enzyme activity. Immunoassay. Prerequisites: admission to the major; grade of C– or better in BENG 161B and BIBC 103 (may be taken concurrently). (S) 166A. Cell and Tissue Engineering (4) Engineering analysis of physico-chemical rate processes that affect, limit, and govern the function of cells and tissues. Cell migration, mitosis, apoptosis, and differentiation. Dynamic and structural interactions between mesenchyme and parenchyme. The role of the tissue microenvironment including cell-cell interactions, extracellular matrix, and growth factor communication. The design of functional tissue substitutes including cell and material sourcing, scale-up and manufacturability, efficacy and safety, regulatory, and ethical topics. Clinical Applications. Prerequisite: admission to the major or consent of department; senior standing and (BENG 103B OR BENG 112B). (F) 168. Biomolecular Engineering (4) Basic molecular biology; recombinant DNA technologies; design and manufacture of recombinant proteins and genetically engineered cells; architecture and mechanism of molecular nano-machineries that perform gene regulation, energy conversion, enzymatic catalysis, and active transport. Prerequisites: BILD 1 and BENG 100; majors only or consent of instructor. (S) 172. Bioengineering Laboratory (4) A laboratory course which demonstrates basic concepts of bioengineering design through experimental procedures involving humans and animals. Statistical principles of experimental design. Study of possible errors. Experiments include nerve action, electrocardiography, mechanics of muscle, membranes, and noninvasive diagnostics in humans. Prerequisites: grade of C– or better in MAE 170 and junior or senior standing in the major. (S) 181/BIMM 181/CSE 181. Molecular Sequence Analysis (4) (Cross-listed as BIMM 181 and CSE 181.) This course covers the analysis of nucleic acid and protein sequences, with an emphasis on the application of algorithms to biological problems. Topics include sequence alignments, database searching, comparative genomics, and phylogenetic and clustering analyses. Pairwise alignment, multiple alignment, DNA sequencing, scoring functions, fast database search, comparative genomics, clustering, phylogenetic trees, gene finding/DNA statistics. Prerequisites: CSE 100 or Math. 176, CSE 101 or Math. 188, BIMM 100 or Chem. 114C; Bioinformatics majors only. (S) 182/BIMM 182/CSE 182/CHEM182. Biological >Databases (4) (Cross-listed as BIMM 182, CSE 182, and Chem. 182.) This course provides an introduction to the features of biological data, how those data are organized efficiently in databases, and how existing data resources can be utilized to solve a variety of biological problems. Object oriented databases, data modeling and description. Survey of current biological database with respect to above, implementation of database focused on a biological topic. Prerequisite: CSE 100 or Math. 176; Bioinformatics majors only. (F) 183. Applied Genomic Technologies (4) Principles and technologies for using genomic information for biomedical applications. Technologies will be introduced progressively, from DNA to RNA to protein to whole cell systems. The integration of biology, chemistry, engineering, and computation will be stressed. Topics include: Technology for the Genome, DNA Chips, RNA Technologies, Proteomic Technologies, Physiomic and Phenomic Technologies, Analysis of Cell Function. Prerequisite: grade of C– or better in BIMM 100 or Chem 114C; BICD 110; Bioinformatics majors only. (F) 184/BIMM 184/CSE 184. Computational Molecular Biology (4) (Cross-listed as BIMM 184 and CSE 184.) This advanced course covers the application of machine learning and modeling techniques to biological systems. Topics include gene structure, recognition of DNA and protein sequence patterns, classification, and protein structure prediction. Pattern discovery, hidden Markov models/support vector machines/neural network/profiles, protein structure prediction, functional characterization of proteins, functional genomics/proteomics, metabolic pathways/gene networks. Prerequisites: BENG 181 or BIMM 181 or CSE 181; BENG 182 or BIMM 182 or CSE 182 or CHEM 182; Bioinformatics majors only. (W) 186A. Principles of Biomaterials Design (4) Fundamentals of materials science as applied to bioengineering design. Natural and synthetic polymeric materials. Materials characterization and design. Wound repair, blood clotting, foreign body response, transplantation biology, biocompatibility of materials, tissue engineering. Artificial organs and medical devices. Government regulations. Patenting. Economic impact. Ethical issues. A term project and oral presentation are required. Prerequisite: grade of C– or better in BENG 112B or senior standing in Bioengineering: Biotechnology major; majors only or consent of department. (F) 186B. Principles of Bioinstrumentation Design (4) Biophysical phenomena, transducers, and electronics as related to the design of biomedical instrumentation. Potentiometric and amperometric signals and amplifiers. Biopotentials, membrane potentials, chemical sensors. Electrical safety. Mechanical transducers for displacement, force, and pressure. Temperature sensors. Flow sensors. Light-based instrumentation. Prerequisites: grade of C– or better in MAE 140 and MAE 170. (W) 186C. Bioengineering Design (4) Development of an original bioengineering design described in a formal engineering report, leading to a major and complete design experience. Emphasis on engineering analysis and application of methodology from various branches of applied mechanics. Includes analysis of economic, environmental, manufacturability, ethical, health and safety, social, political issues, and application of governmental regulations. A term project and oral presentation are required. Prerequisites: grades of C– or better in BENG 103B, BENG 106B, BENG 112B, and BENG 186B; CENG 101A, MAE 107 and MAE 130A; majors only. (S) 191. Senior Seminar I: Professional Issues in Bioengineering (2) Role of bioengineers in industry. Professional identity. Structure of bioengineering industries and product development process. Job market analysis. Current employment opportunities. Recruiting process and interview. Analysis of the employer. Marketing vs. engineering. Management by objective. Role of higher degrees. Prerequisite: consent of instructor. (W) 195. Teaching (2-4) Teaching and tutorial assistance in a bioengineering course under supervision of instructor. Not more than four units may be used to satisfy graduation requirements. (P/NP grades only.) Prerequisites: B average in the major and departmental approval. (F,W,S) 196. Bioengineering Industrial Internship (1-4) Under the joint supervision of a faculty adviser and industry mentor, the student will work at a bioengineering industrial site to gain practical bioengineering experience. No more than twelve units may be used to satisfy graduation unit requirements. (P/NP grades only) Prerequisites: consent of department and completion of all lower-division course requirements, including general-science requirements. Some laboratory experience is needed. Completion of ninety units with a 2.5 GPA and consent of a bioengineering faculty coordinator. (F,W,S,Su) 197. Engineering Internship (1-4) An enrichment program, available to a limited number of undergraduate students, which provides work experience with industry, government offices, hospitals, and their practices. Subject to the availability of positions, students will work in a local industry or hospital (on a salaried or unsalaried basis) under the supervision of a faculty member and industrial supervisor. Coordination of the Engineering Internship is conducted through UCSD’s Academic Internship Program. Time and effort to be arranged. Final report required. Prerequisites: completion of ninety units with a 2.5 GPA and consent of a bioengineering faculty coordinator. (F,W,S,Su) 198. Directed Group Study (1-4) Directed group study, on a topic or in a field not included in the regular department curriculum, by arrangement with a bioengineering faculty member. (P/NP grades only.) Prerequisites: consent of instructor; upper-division standing, completion of ninety units of UCSD undergraduate study, a minimum UCSD GPA of 2.5, and a completed and approved “Special Studies” form, “Application for UCSD Special Studies Course Enrollment.” (F,W,S) 199. Independent Study for Undergraduates (4) Independent reading or research by arrangement with a bioengineering faculty member. (P/NP grades only.) Prerequisites: consent of instructor; upper-division standing, completion of ninety units of UCSD undergraduate study, a minimum UCSD GPA of 2.5, and a completed and approved “Special Studies” form, “Application for UCSD Special Studies Course Enrollment.” (F,W,S,Su) Graduate202/CSE 257A. Bioinformatics II: Sequence and Structure Analysis—Methods and Applications (4) Introduction to methods for sequence analysis. Applications to genome and proteome sequences. Protein Structure, sequence-structure analysis. Prerequisite: Pharm. 201 or consent of instructor. (W) 203. Bioinformatics III: Genomes Analysis (4) Annotating genomes, characterizing functional genes, profiling, reconstructing pathways. Prerequisites: Pharm. 201, BENG 202/CSE 257A or consent of instructor. (S) 207. Topics in Bioengineering (4) Course given at the discretion of the faculty on current topics of interest in bioengineering. (F,W,S) 208. Topics in Bioengineering with Lab (2 or 4) A course to be given at the discretion of the faculty on topics of current interest in engineering science. This course is intended to be a lecture and lab companion topics course. Prerequisite: consent of instructor. (S) BENG 209. Continuum Mechanics Applied to Medicine/Biology Introduction to the basic definitions of Continuum Mechanics and their mathematical formulation at the graduate level with applications to problems in medicine and biology. This course is intended for students with little or no background in mechanics; it is an introduction to the Biomechanics courses BENG 250 A-B in the Department of Bioengineering and to Solid and Fluid Mechanics courses MAE 210A and MAE 231A in the Department of Mechanical and Aerospace Engineering. This course should NOT be taken concurrently with MAE 210A or MAE 231A. Prerequisite: consent of instructor. (F) BENG 211. Systems Biology and Bioengineering I: Biological Components Components of biological systems, their biochemical properties and function. The technology used for obtaining component lists. Relationship within and integration of component lists. Structured vocabularies and component ontologies. Algorithms for comparative approaches in deciphering and mining component lists. Prerequisite: BENG 230A or BIMM 100 or consent of instructor.(F) BENG 212. Systems Biology and Bioengineering II: Network Reconstruction This course will cover the process of reconstructing complex biological reaction networks. Reconstruction of metabolic networks, regulatory networks and signaling networks. Bottom-up and top-down approaches. The use of collections of historical data. The principles underlying high-throughput experimental technologies and examples given on how this data is used for network reconstruction, consistency checking, and validation. Prerequisite: BENG 211 or consent of instructor. (W) BENG 213. Systems Biology and Bioengineering III: Building and Simulating Large-scale In Silico Models Mathematical models of reconstructed reaction networks and simulation of their emergent properties. Classical kinetic theory, stochastic simulation methods and constraints-based models. Methods that are scalable and integrate multiple cellular processes will be emphasized. Existing genome-scale models will be described and computations performed. Emphasis will be on studying the genotype-phenotype relationship in an in silico model driven fashion. Comparisons with phenotypic data will be emphasized. Prerequisite: BENG 212 or consent of instructor. (S) 220. Project Design and Development (4) The design of a research/development project for an industrial setting. Project objectives and organization, funding sources, review of previous developments in the area, proposal writing and review, project management, intellectual property, regulatory issues. The term project will involve preparing a small business proposal for development of a medical device. Prerequisite: open to students with graduate standing in bioengineering. (W) 225. BioBusiness: Starting, Growing, and Harvesting a Biotech Company Biotech is a special breed of business, especially in the start-up and early phases. Whether you are considering joining a biotech start-up or want to be successful in a life science organization, it pays to understand this unique business model. In this course, you will study and analyze (1) start-up proposals (2) the genesis of the biotech industry (3) biotech categories and growth strategies (4) the process of spinning out viable product concepts from academia (5) financing techniques (6) business development (7) acquisition/IPO valuation methods (8) potentially disruptive technologies. The format is highly interactive and learning is enhanced by means of exercises, team presentations, and case studies. Prerequisites: for bioengineering MEng degree students or consent of instructor. (F,W) 230A. Biochemistry (4) A graduate course in biochemistry especially tailored to the requirements and background of bioengineering graduate students. It will cover the important macro- and small molecules in cells that are the major constituents, or that function as signaling molecules or molecular machineries. The structures, pathways, interactions, methodologies, and molecular designs using recombinant DNA technology will be covered. Prerequisites: BIPN 100 and 102, or consent of instructor. (F) 230B. Cell and Molecular Biology (4) A general survey of structure-function relationships at the molecular and cellular levels. Emphasis on basic genetic mechanisms; control of gene expression; membrane structure, transport and traffic; cell signaling; cell adhesion; mechanics of cell division; and cytoskeleton. Prerequisites: BIPN 100 and 102, and BENG 230A, or consent of instructor. (W) 230C. Cardiovascular Physiology (4) Physical concepts of behavior of heart, large blood vessels, vascular beds in major organs and the microcirculation. Physical and physiological principles of blood flow, blood pressure, cardiac work, electrophysiology of the heart. Special vascular beds, including their biological and hemodynamic importance. Integration through nervous and humoral controls. Prerequisites: BIPN 100 ,102 , and BENG 230B, or consent of instructor. (S) 230D. Respiratory and Renal Physiology (4) Mechanics of breathing. Gas diffusion. Pulmonary blood flow. Stress distribution. Gas transport by blood. Kinetics of oxygen and carbon dioxide exchange. VA/Q relations. Control of ventilation. Glomerular and proximal tubule functions. Water metabolism. Control of sodium and potassium in the kidney. Prerequisites: BIPN 100 ,102 , and BENG 230C, or consent of instructor. (F,W,S) 238. Molecular Biology of the Cardiovascular System (4) This course will give an overview of heart and vascular development and disease from a molecular biological perspective. Current approaches for generating mouse models of cardiovascular disease and recently developed technologies for physiological assessment in small animal models will be presented. (S) 241A. Foundations of Tissue Engineering Science (4) Molecular and cell biological basis of tissue engineering science. Paracrine control of tissue growth and differentiation. Biomechanics and the molecular basis of cell-cell and cell-matrix interactions. Cell motility, mechanics of tissue growth and assembly, tissue repair. Mass transfer in tissues. Microcirculation of blood and lymph. Prerequisite: BENG 230A or consent of instructor. (S) 241B. Methods in Tissue Engineering Science (4) Isolation of cells, cell and tissue culture systems. Fluorescence and confocal microscopy. Intracellular imaging. Mechanical testing of tissues. Micromechanical measurement and analysis of cell deformability and cell interaction. Methods in microcirculation and angiogenesis. Prerequisite: BENG 241A or consent of instructor. (F) 241C. Applications of Tissue Engineering Science (4) A lecture/seminar series featuring speakers from academia and industry emphasizing principles of tissue engineering science as applied to clinical medicine and industrial production. Topics include skin replacement, guide tubes for nerve regeneration, blood substitutes, pancreatic islet replacement, and drug delivery devices, among others. Ethics of tissue replacement. Prerequisite: BENG 241B or consent of instructor. (W) BENG 247A. Advanced BioPhotonics Basic physics and chemistry for the interaction of photons with matter, including both biological and synthetic materials; use of photonic radiation pressure for manipulation of objects and materials; advanced optoelectronic detection systems, devices and methods, including time resolved fluorescent and chemiluminescent methods, fluorescent energy transfer (FRET) techniques, quantum dots, and near-field optical techniques; underlying mechanisms of the light sensitive biological systems, including chloroplasts for photosynthetic energy conversion and the basis of vision processes. Prerequisite: graduate standing. (F) BENG 247B. BioElectronics Topics to be covered will include photolithographic techniques for high-density DNA microarray production, incorporation of CMOS control into electronic DNA microarrays, direct electronic detection technology used in microarrays and biosensor devices, and focus on problems related to making highly integrated devices (lab-on-a-chip, in vivo biosensors, etc.) form heterogeneous materials and components. Prerequisite: graduate standing. (W) BENG 247C. Bionanotechnology Topics include: nanosensors and nanodevices for both clinical diagnostics and biowarfare (bioterror) agent aetection; nanostructures for drug delivery; nanoarrays and nanodevices; use of nanoanalytical devices and systems; methods and techniques for modification or functionalization of nanoparticles and nanostructures with biological molecules; nanostructural aspects of fuel cells and biofuel cells; potential use of DNA and other biomolecules for computing and ultra-high-density data storage. Prerequisite: graduate standing. (S) 250A. Biomechanics (4) An introduction to biomechanics and transport phenomena in biological systems at the graduate level. Biorheology, biosolid mechanics, muscle mechanics, mass transfer, momentum transfer, energy transfer. Prerequisites: CENG 103B and BENG 112B, or consent of instructor. (W) 250B. Advanced Biomechanics (4) Modern development of biomechanics at an advanced mathematical level. Selected topics in the dynamics of heart, pulsatile, blood flow, microcirculation, and muscle mechanics. Prerequisite: BENG 253 or consent of instructor. (S) 253. Biomedical Transport Phenomena (4) Nonequilibrium thermodynamic analysis of transport phenomena. The osmotic effect. Diffusion and exchange in biological systems. Prerequisite: consent of instructor. (W) 264. Advanced Biomedical Transport Phenomena (4) Applications of heat, mass, and momentum transfer in biomedical systems. Extension of the principles encountered in BENG 252B-C to practical biomedical systems. Prerequisite: BENG 252B-C. 267. Microcirculation in Health and Disease (4) Structural and functional aspects of transport and blood-tissue exchange in key organs during circulatory shock, bacterial toxemia, hypertension. Physical and ultrastructural techniques used to analyze small-vessel dynamics. Prerequisite: consent of instructor. 275. Computational Biomechanics (4) Finite element methods for anatomical modeling and boundary value problems in the biomechanics of tissues and biomedical devices. Nonlinear biodynamics, heat flow, cardiac impulse propagation, anatomic modeling, and biomechanics. Prerequisite: consent of instructor. (F) BENG 280A. Principles of Biomedical Imaging Fundamentals of Fourier transform and linear systems theory including convolution, sampling, noise, filtering, image reconstruction and visualization with an emphasis on applications to biomedical imaging. Examples from optical imaging, CT, MR, ultrasound, nuclear, PET, and radiography. Prerequisite: consent of instructor. (F) BENG 280B. Comparative Biomedical Imaging Application of biomedical imaging to the measurement of structure, function, and dynamics of organ systems from the microscopic to the organ level. Emphasis on detailed evaluation and comparison of specific imaging modalities. Prerequisite: consent of instructor. (W,S) 281. Seminar in Bioengineering (1) Weekly seminars by faculty, visitors, postdoctoral research fellows, and graduate students concerning research topics in bioengineering and related subjects. May be repeated for credit. This course does not apply toward the M.S. graduation requirements. (S/U grades only.) (F,W,S) 290. Bioengineering Special Graduate Seminar (1-2) Seminars by faculty, visitors, post-doctoral research fellows, and/or graduate students in selected topic(s) in bioengineering and/or related subjects. This course does not apply toward M.S. graduation requirements. 295. Bioengineering Design Project and Industrial Training (4) Independent work by graduate students focused on design, applied research, and professional experience. Prerequisite: consent of department and bioengineering faculty adviser. (F,W,S) 296. Independent Study (4) Prerequisite: consent of instructor. 298. Directed Group Study (1-4) Directed group study on a topic or in a field not included in regular department curriculum, by special arrangement with a faculty member. Prerequisite: consent of instructor. (S/U grade only.) 299. Graduate Research (1-12) (S/U grades only.) 501. Teaching Experience (2) Teaching experience in an appropriate bioengineering undergraduate course under direction of the faculty member in charge of the course. Lecturing one hour per week in either a problem-solving section or regular lecture. (S/U grade only.) Prerequisites: consent of instructor and departmental approval. (F,W,S)
|
