Upper-Division Requirements
- Two quarters of physical chemistry (Chem. 126-127 recommended; 131-133
acceptable).
- Three quarters of organic chemistry (Chem. 140A-C or 141A-C).
- Three quarters of biochemistry (Chem. 114A-B-C).
- Three laboratory courses (Chem. 143AM or 143A, 143B and either 112A,
112B or 143C).
- One quarter of pharmacology and toxicology (Chem. 118).
- One chemistry elective course.
- If ACS certification is desired, Chem. 120A, plus two additional laboratory
courses, are required. Any of these courses would satisfy #6. above.
Suggested Program for Pharmacological Chemistry B.S. Major:
FALL WINTER SPRING______
FRESHMAN YEAR
Chem. 6A Chem. 6B Chem. 6C
Math. 20A Math. 20B Math. 20C
Biol. BILD 1 Chem. 6BL
Chem. 92____
SOPHOMORE YEAR
Chem. 140A Chem. 140B Chem. 140C
Chem. 6CL Chem. 143AM Chem. 143B
Math. 21D Phys. 2A Phys. 2B____
JUNIOR YEAR
Chem. 114A Chem. 114B Chem. 114C
Phys. 2D Econ. 1A/1B Biol. BILD 3
Chem. 143C Biol. BILD 2 Phys. 2CL___
SENIOR YEAR
Chem 120A/elec Bio. lab* Chem. 118
Chem. 126 Chem. 127____________________
*Bio. BICD 101, 111, 131, or BIPN 105.
Honors Program
The Department of Chemistry and Biochemistry offers an Honors Program
to those students who have demonstrated excellence in any of the seven
majors. Students are eligible for Departmental Honors at graduation when
they have:
- Achieved a GPA of 3.2 overall and 3.4 in chemistry courses.
- Completed a minimum of eight units of Chem. 199, distributed over
at least two quarters. A student who registers for 199 and subsequently
fails to complete the Honors Program may apply up to four units to any
major that normally allows 199 as elective credit.
- Submitted a final honors research report to three UCSD faculty members,
including their research adviser, for approval.
- Presented an oral report about their research before a group of at
least three faculty. This can be at an undergradute research conference
or at a seminar involving honors students and faculty.
Students who are interested in the Honors Program should contact the
Undergraduate Coordinator in 4010 York Hall, and are invited to do so
at any time.
Education Abroad
Majors are encouraged to explore the programs that allow students to
study abroad or at other U.S. universities for a term or longer. See an
adviser for details.
Minor Programs in Chemistry
A typical minor in chemistry consists of three lower-division lecture
courses and at least one laboratory course, followed by a minimum of five
upper-division courses, including at least one laboratory course, focused
in physical, inorganic, organic, environmental chemistry, or biochemistry.
Upper-division courses required by a student's major may not be applied
toward a minor. Upper-division courses for the minor must be taken at
UCSD and must be taken for a letter grade. The minimum GPA requirement
for the minor is a 2.0.
Contiguous Bachelor's/Master's Degree Program
The department offers a contiguous bachelor's/master's degree
program. It is limited to students with a bachelor's degree from
the Department of Chemistry and Biochemistry at UCSD. A minimum undergraduate
GPA of 3.0 is required for admission. Contact the Student Affairs Office
in 4010 York Hall for more information.
The Graduate Program
Graduate students are accepted to the Department of Chemistry and Biochemistry
for study toward the Ph.D. in chemistry and the Ph.D. in chemistry with
specialization in bioinformatics. Students interested in the bioinformatics
specialization should contact the Graduate Student Affairs Office for
more information.
The goal of the Ph.D. in chemistry is to prepare students for careers
in science by expanding their knowledge of chemistry while developing
their ability for critical analysis, creativity, and independent study.
The program is designed to encourage initiative and to stimulate enjoyment
and development of the student's area of research expertise as well
as the broader aspects of scientific inquiry and enlightenment.
Research
Students choose their research concentration from programs in biochemistry,
biophysics, bioinformatics, inorganic, organic, physical and theoretical
chemistry, surface and materials chemistry, and atmospheric and environmental
chemistry. Opportunities for scientific discovery are also abundant through
the department's extensive collaborations with investigators in the
physical, biological, and engineering sciences. This includes on-campus
collaborations with faculty in the Material Science Program, School of
Medicine, and Scripps Institution of Oceanography. There are also off-campus
interactions with scientists at nearby research facilities such as the
Salk Institute and The Scripps Research Institute. Excellent state-of-the-art
facilities and equipment support all the research programs. The department's
Industrial Relations Program interfaces with national and local chemical,
biotechnology, and pharmaceutical industries to encourage technology transfer
and to assist postgraduates interested in industrial careers.
Research Adviser
A first-year adviser guides students until a research adviser is chosen.
Most of a student's efforts in graduate school are directed toward
research for the doctoral dissertation, and selection of a research adviser
is of utmost importance. To assist students with this critical decision,
all chemistry and biochemistry faculty present research seminars in the
fall quarter. Inorganic, organic, and physical chemistry students then
consult with faculty to discuss research opportunities. Biochemistry students
do research rotations with various faculty members. Although students
have until the end of the first year to join a laboratory, most start
their research studies by mid-year.
Requirements for the Ph.D.
Placement Examinations and Course Work
Entering students take written placement examinations in biochemistry,
inorganic, organic, and physical chemistry. The purposes of these exams
are to assist with advising and to assure that students have the breadth
and level of competence needed for graduate studies. Deficiencies must
be remedied in the first year. Three of four exams must be passed, including
the one in the student's research area.
First-year students normally take at least six of the graduate courses
listed below based on the results of their placement examinations, their
research programs, and their specialized interests. Chem. 250 is required.
Undergraduate courses and courses offered through other departments may
also be taken, depending on the student's research area. By the second
year, the emphasis is on thesis research, and a lighter load of courses
is taken, although participation in seminars and informal study groups
continues.
Departmental Examination
In the winter quarter of the second year, a student's progress
in research and graduate studies is evaluated through the departmental
examination, which includes presentation and critical discussion of a
recent research article. Students are also evaluated on their general
knowledge of their particular field of study. Students may also be asked
about progress on their dissertation.
Qualifying Examination
By the end of the third year, students defend the topic, preliminary
findings, and future research plans of their dissertation. Passing this
defense qualifies the student to advance to candidacy for the dissertation.
A dissertation committee composed of five faculty, one of whom is the
research adviser, provides consultation and evaluation for the dissertation
project.
Dissertation
The dissertation is normally completed in the fourth or fifth year.
This body of research is expected to make an innovative contribution to
the field of chemistry. Ph.D. candidates present a seminar summarizing
their research accomplishments and defend their thesis in an oral examination
before their dissertation committee.
Teaching
Experience in teaching is a vital and integral part of every graduate
student's training, and all students participate in the instructional
activities of the undergraduate curriculum. Course credit for the teaching
apprenticeship is earned by enrolling in Chem. 500. Excellence in teaching
is stressed, and the department provides a thorough training program covering
the fundamentals of teaching as well as other useful information and techniques
for effective instruction. Further training is provided by the campus's
Center for Teaching Development. Faculty and the students taught evaluate
the performance of teaching assistants every quarter and awards are bestowed
annually for outstanding performance as a teaching assistant.
Language Requirement
Students whose native language is not English must demonstrate a mastery
of English adequate to complete the teaching requirement. Deficien-cies
must be remedied by the end of the first year of academic residency. For
native English speakers, there is no foreign-language requirement.
Time Limits
In accordance with UCSD policy, students must advance to candidacy by
the end of four years. Total university support cannot exceed six and
one-third years. Total registered time at UCSD cannot exceed seven and
one-third years.
Seminars
Seminars by researchers from other universities, national laboratories,
and industry are another basic and important aspect of the graduate curriculum.
Seminars are presented weekly in biochemistry, inorganic, organic, and
physical chemistry. Department colloquia are given on topics of general
interest to the department. Seminars are also sponsored by many other
departments and institutes.
Financial Support
The department supports all first-year students in good academic standing
from a variety of sources, including teaching and research assistantships,
training grants, fellowships, and awards. A stipend is paid in addition
to fees and, if applicable, tuition. Continuing students who do not have
fellowships or awards are normally supported as research assistants by
their thesis adviser.
Admissions
The department seeks bright, motivated students and welcomes all such
applications. To make admissions decisions, the department considers an
applicant's statement of purpose and research interests, GRE scores
on the general test plus either the advanced chemistry or advanced biochemistry
test, undergraduate record, quality of the undergraduate university, letters
of recommendation, and research experience and publications. Applicants
whose native language is not English must also submit TOEFL scores. Admis-sions
to the graduate program is for fall quarter. Applications received by
January 15 receive priority consideration.
Students who have a master's degree with strong course records
and with research experience are encouraged to apply. They normally pass
the Qualifying Examination and graduate at an accelerated pace.
Joint Doctoral Program with San Diego State University
The Department of Chemistry and Biochemistry at UCSD and the Department
of Chemistry at San Diego State University offer a joint program of graduate
study leading to the Ph.D. degree in chemistry. More information is available
in the current edition of the Bulletin of the Graduate Division
of San Diego State University.
Courses
Lower-Division
4. Basic Chemistry (4)
Chemistry 4 is a one-quarter course for science majors with insufficient
preparation to start the Chem. 6 sequence. Emphasis is on learning how
to solve quantitative problems. Topics include nomenclature, stoichiometry,
and the periodic table. Cannot be taken for credit after any other chemistry
course. Includes a combined laboratory and discussion-recitation each
week. Prerequisite: Math. 4C. A materials fee is required for this
course. Cannot be taken for credit after any other chemistry course. (F)
6A. General Chemistry (4)
First quarter of a three-quarter sequence intended for science and engineering
majors. Topics include: stoichiometry, gas laws, bonding, atomic theory,
quantum theory, and thermochemistry. Three hours' lecture, one hour
recitation. Prerequisites: proficiency in high school chemistry or
physics. Math 10A (may be taken concurrently). (F,W,S)
6AH. Honors General Chemistry (4)
First quarter of a three-quarter honors sequence intended for well-prepared
science and engineering majors. Topics include: stoichiometry, gas laws,
bonding, atomic theory, quantum theory, and thermochemistry. Three hours
lecture, one hour recitation. Prerequisites: proficiency in high school
chemistry, physics and mathematics. Concurrent enrollment in Math. 20A
or higher level calculus required. (F)
6B. General Chemistry (4)
Second quarter of a three-quarter sequence intended for science and engineering
majors. Topics include: molecular geometry, condensed phases and solutions,
chemical equilibrium, acids and bases and thermodynamics. Three hours'
lecture, one hour recitation. Prerequisites: Chem. 6A; Math. 20A or
10A. (F,W,S)
6BH. Honors General Chemistry (4)
Second quarter of a three-quarter honors sequence intended for well-prepared
science and engineering majors. Topics include: molecular geometry, condensed
phases and solutions, chemical equilibrium, acids and bases and thermodynamics.
Three hours lecture, one hour recitation. Prerequisites: Chem. 6AH;
Math. 20A. (W)
6BL. Introductory Inorganic Chemistry Laboratory (3)
Introduction to experimental procedures used in synthetic, analytical,
and physical chemistry. Prerequisite: Chem. 6A. If 6BL is a requirement
for your major, it should be taken concurrently with 6B, or 6C. A materials
fee is required for this course. (F,W,S)
6C. General Chemistry (4)
Third quarter of a three-quarter sequence intended for science and engineering
majors. Topics include: electrochemistry, kinetics, coordination chemistry,
nuclear chemistry, and an introduction to organic and biochemistry. Three
hours' lecture, one hour recitation. Prerequisite: Chem. 6B; Chem.
6BL may be taken concurrently. (F,W,S)
6CH. Honors General Chemistry (4)
Third quarter of a three-quarter honors sequence intended for well-prepared
science and engineering majors. Topics include: electrochemistry, kinetics,
coordination chemistry, nuclear chemistry, and an introduction to organic
and biochemistry. Three hours lecture, one hour recitation. Prerequisites:
Chem. 6BH; Math. 20B. Chem. 6BL may be taken concurrently. (S)
6CL. Introductory Analytical Chemistry (4)
A laboratory course with emphasis on safe, accurate, and precise experimental
techniques in chemistry, including quantitative analysis and instrumental
methods, usually taken concurrently with Chem. 6C, but required for only
certain majors. Prerequisite: Chem. 6BL. A materials fee is required
for this course. (F,W,S)
11. The Periodic Table (4)
Introduction to the material world of atoms and small inorganic molecules.
Intended for nonscience majors. Can be skipped by students with good knowledge
of high school chemistry. Cannot be taken for credit after any other general
chemistry course. (F)
12. Molecules and Reactions (4)
Introduction to molecular bonding and structure and chemical reactions,
including organic molecules and synthetic polymers. Intended for nonscience
majors. Prerequisite: Chem. 11 or good knowledge of high school chemistry.
Cannot be taken for credit after any organic chemistry course. (W)
13. Chemistry of Life (4)
Introduction to biochemistry for nonscience majors. Prerequisite: Chem.
12. Cannot be taken for credit after any biochemistry course. (S)
15. Chemistry of the Universe (4)
This is a one-quarter, nonmathematical chemistry course for nonscience
majors covering the origin of the universe, the elements, and the formation
of the solar system. The evolution of the Earth's atmosphere, hydrosphere,
geosphere, and biosphere will be covered, as well as contemporary problems
in environmental chemistry. Cannot be taken for credit after any other
chemistry course.
90. Undergraduate Seminar (1)
The seminar will focus on a variety of issues and special areas in the
field of chemistry.
91. Undergraduate Honors Seminar (1)
A seminar intended for exposing undergraduate students, especially freshmen
and sophomores, to exciting research programs conducted by the faculty.
Enrollment is limited.
92. Undergraduate Pharmacology Seminar (1)
Selected topics in pharmacology and toxicology.
Upper-Division
105A. Physical Chemistry Laboratory (5)
Laboratory course in experimental physical chemistry. Prerequisites:
Chem. 6CL and Phys. 2CL or equivalent, Chem. 131 or 133 or 126 or 127.
A materials fee is required for this course. (F,W,S)
105B. Physical Chemistry Laboratory (4)
Laboratory course in experimental physical chemistry. Prerequisites:
Chem. 105A and 133. A materials fee is required for this course. (F,W,S)
106. Instrumental Analysis Laboratory (4)
Instrumental methods for analytical chemistry emphasizing physical principles
underlying both the instruments and the analytical methods. Prerequisite:
Chem. 105A. A materials fee is required for this course. (W)
107. Synthetic Macromolecules (4)
The organic and physical chemistry of high polymers with emphasis on synthesis,
structure, characterization, and properties. Polymers as materials are
important as films, fibers, and elastomers. They play an ever-increasing
role in science, technology, and medicine. Prerequisites: Chem. 126
or 131 and 140B or 141B. (May not be offered every year.)
110. Biotechnology and Drug Discovery (2)
This seminar course will explore how the biotechnology and pharmaceutical
industry utilizes chemistry, biochemistry, and molecular biology to discover
and develop today's pharmaceutical agents (drugs): process of lead
discovery, development, animal toxicity, clinical trials, manufacturing,
quality assurance, regulatory affairs, etc. Guest lecturers will be from
the local biotechnology industry. Prerequisites: biochemistry background
preferred. (S)
112A. Molecular Biochemistry Laboratory (6)
The application of techniques, including electrophoresis, peptide mapping
and sequencing, affinity chromatography, amino acid analysis, gas-liquid
chromatography, and enzyme functions and the chemistry of lipids, carbohydrates,
and nucleic acids. Prerequisites: Chem. 140A-B-C or 141A-B-C, 143A-B,
114A-B. (Some of these courses may be taken concurrently.) (Note:
Students may not receive credit for both Chem. 112A and BIBC 103.) A materials
fee is required for this course. (W)
112B. Molecular Biochemistry Laboratory (6)
This laboratory will introduce the students to the tools of molecular
biology and will involve experiments with recombinant DNA techniques.
Prerequisites: Chem. 114A-B, Chem. 114C (may be taken concurrently);
Chem. 143A and 143B. (Note: Students may not receive credit for both
Chem. 112B and BIMM 101.) A materials fee is required for this course.
(S)
113. Chemistry of Biological Macromolecules (4)
A discussion of the structural principles governing biological macromolecules,
the techniques used in their study, and how their functional properties
depend on three-dimensional structure. Prerequisites: elementary organic
and physical chemistry. (May not be offered every year.)
114A. Biochemical Structure and Function (4)
Introduction to biochemistry from a structural and functional viewpoint.
Prerequisite: elementary organic chemistry strongly recommended (Chem.
141A or 140A). (Note: Students may not receive credit for both Chem. 114A
and BIBC 100.) (F)
114B. Biochemical Energetics and Metabolism (4)
This course is an introduction to the metabolic reactions in the cell
which produce and utilize energy. The course material will include energy-producing
pathways: glycolysis, Krebs cycle, oxidative phosphorylation, fatty-acid
oxidation. Biosynthesisamino acids, lipids, carbohydrates, purines,
pyrimidines, proteins, nucleic acids. Prerequisite: Chem. 114A.
(Note: Students may not receive credit for both Chem. 114B and BIBC 102)
(W)
114C. Biosynthesis of Macromolecules (4)
This course is a continuation of the introduction to biochemistry courses
(114A and 114B). This quarter reviews the mechanisms of biosynthesis of
macromoleculesparticularly proteins and nucleic acids. Emphasis
will be placed on how these processes are controlled and integrated with
the metabolism of the cell. Prerequisite: Chem. 114B. (Note: Students
may not receive credit for both Chem. 114C and BIMM 100.) (S)
114D. Molecular and Cellular Biochemistry (4)
This course represents a continuation of 114C, or an introductory course
for first- and second-year graduate students, and covers topics in molecular
and cellular biochemistry. Emphasis will be placed on contemporary approaches
to the isolation and characterization of mammalian genes and proteins,
and molecular genetic approaches to understanding eukaryotic development
and human disease. Prerequisite: Chem. 114A-C or consent of instructor.
(May not be offered every year.)
115. Modeling Biological Macromolecules (4)
Use of computer graphics and modeling methods in the study of biological
macromolecules. The course will cover basic methods and techniques. The
objective is to provide a good working knowledge of the critical features
of the methods and to provide a foundation for further study for those
who wish to pursue these methods as research topics. Prerequisite:
Chem. 114A or equivalent. (May not be offered every year.)
116. Chemistry of Enzyme Catalyzed Reactions (4)
A discussion of the chemistry of representative enzyme catalyzed reactions
is presented. Enzyme reaction mechanisms and their relation to enzyme
structure are emphasized. Prerequisites: elementary physical chemistry,
organic chemistry, and biochemistry. (May not be offered every year.)
117. Biochemistry of Human Disease (4)
An advanced course in biochemistry which will deal primarily with the
molecular basis of human disorders. Prerequisite: elementary biochemistry.
(May not be offered every year.)
118. Pharmacology and Toxicology (4)
A survey of the biochemical action of drugs and toxins as well as their
absorption and excretion. Prerequisites: Chem. 141A-B-C (or Chem. 140ABC),
Chem. 114A-B-C and admission to Pharmacological Chemistry major, or consent
of instructor.
120A. Inorganic Chemistry (4)
The chemistry of the main group elements is presented in terms of atomic
structure, ionic and covalent bonding. Structural theory involving s,
p, and unfilled d orbitals is described. Thermodynamic and spectroscopic
criteria for structure and stability of compounds are presented and chemical
reactions of main group elements discussed in terms of molecular structure
and reactivity. Prerequisites: a general chemistry course. Chem. 140A
or 141A or equivalent course is recommended. (F)
120B. Inorganic Chemistry (4)
A continuation of the discussion of structure, bonding, and reactivity
with emphasis on transition metals and other elements using filled d orbitals
to form bonds. Coordination chemistry is discussed in terms of valence
bond, crystal field, and molecular orbital theory. The properties and
reactivities of transition metal complexes including organometallic compounds
are discussed. Prerequisite: Chem. 120A. (W)
122. Biochemical Evolution (4)
This course emphasizes the chemical aspects of evolution, including the
origin of living systems on earth, primitive energy acquisition devices,
the coupling of information storage and replication catalysis, protein
evolution, and the biochemical unity and diversity of extant organisms.
Prerequisites: organic chemistry and introductory biochemistry. (May not
be offered every year.)
123. Advanced Inorganic Chemistry Laboratory (4)
Synthesis, analysis, and physical characterization of inorganic chemical
compounds. Prerequisite: Chem. 120A, 120B, 143A, and 143B. A materials
fee is required for this course.
124. Bioinorganic Chemistry (4)
The role of metal ions in biological systems, with emphasis on transition
metal ions in enzymes that transfer electrons, bind oxygen, and fix nitrogen.
Also included are metal complexes in medicine, toxicity, and metal ion
storage and transport. Prerequisites: Chem. 6A-B-C, 114A; or equivalent.
(May not be offered every year.)
126. Physical Chemistry (4)
An introduction to physical chemistry with emphasis on biochemical and
environmental applications. Quantum mechanics, atomic and molecular structure,
spectroscopy. Prerequisites: Chem. 6C, Math. 20D, and Phys. 2D; or
consent of instructor. (F)
127. Physical Chemistry (4)
An introduction to physical chemistry with emphasis on biochemical and
environmental applications. Thermodynamics, first and second laws, thermochemistry,
chemical equilibrium, solutions, kinetic theory, reaction kinetics. Prerequisite:
Chem. 126 or consent of instructor. (W)
128. Physical ChemistryApplied Spectroscopy (4)
The electromagnetic spectrum: rotational, vibrational, and electronic
spectra, nuclear and electron magnetic resonance. X-ray diffraction. Prerequisites:
Chem. 6C, Math. 20C and 20D, Chem. 127 or 132, or consent of instructor.
(S)
131. Physical Chemistry (4)
Thermodynamics, chemical equilibrium, phase equilibrium, chemistry of
solutions. Prerequisites: Chem. 6C, Math. 20AB and Math. 20C or 21C
and Phys. 2AB. Recommended: Math. 20D or 21D and Phys. 2D (may be taken
concurrently); or consent of instructor. (F)
132. Physical Chemistry (4)
Chemical statistics, kinetic theory, reaction kinetics. Prerequisites:
Chem. 131, Math. 20D or 21D; or consent of instructor. Recommended: Phys.
2D. (W)
133. Physical Chemistry (4)
Quantum mechanics, atomic and molecular spectroscopy, molecular structure.
Prerequisites: Chem. 132 and Phys. 2D; or Chem. 6C, Math. 20D or 21D
and Math. 20F, and Phys. 2AB; or consent of instructor. (S)
134. Computer Programming in Chemistry (4)
Use of computer programming in the analysis and presentation of chemical
data (statistical analysis, least squares fitting procedures, titration
curve interpretation, analysis of radioactive decay series, chemical kinetics,
organic synthesis, etc.) Prerequisites: Math. 20A and 20B or equivalent.
(Note: Students may not receive credit for both Chem. 134 and BIBC 115.)
(May not be offered every year.)
135. Molecular Spectroscopy (4)
Time-dependent behavior of systems; interaction of matter with light;
selection rule. Radiative and nonradiative processes, coherent phenomena,
and the density matrices. Instrumentation, measurement, and interpretation.
Prerequisites: Chem. 133 or equivalent; Math. 20D or Chem. 190/290.
(May not be offered every year.)
140A. Organic Chemistry (4)
An introduction to organic chemistry, with emphasis on material fundamental
to biochemistry. Topics include bonding theory, isomerism, stereochemistry,
chemical and physical properties, and an introduction to substitution,
addition, and elimination reactions. Prerequisite: Chem. 6C or equivalent
course in general chemistry. (Note: Students may not receive credit
for both 140A and 141A.) (F,W,S)
140B. Organic Chemistry (4)
A continuation of 140A; acid/base reactions, chemistry of the carbonyl
group, sugars, peptides, nucleic acids and other natural products. Prerequisite:
Chem. 140A (a grade of C or higher in Chem. 140A is strongly recommended).
(Note: Students may not receive credit for both 140B and 141B.) (F,W,S)
140C. Organic Chemistry (4)
A continuation of Chemistry 140A-B. Organic chemistry of biologically
important molecules: carbohydrates, proteins, fatty acids, biopolymers,
natural products, drugs; models for enzymatic reactions, synthetic methods,
and methods of analysis. Prerequisite: Chem. 140B. (Note: Students
may not receive credit for both 140C and 141C.) (F,W,S)
141A. Organic Chemistry (4)
Chem. 141A introduces theoretical and experimental studies of structure
and properties of covalent molecules. Both resonance and simple molecular
orbital descriptions of organic compounds are introduced and spectroscopic
methods for determining electronic and molecular structure are discussed.
Organic reactions are introduced with synthetic and mechanistic examples.
Prerequisites: Chem. 6C (6C may be taken concurrently by good students).
Prior or concurrent physics recommended. (Note: Students may not receive
credit for both Chem. 141A and Chem. 140A.) (F)
141B. Organic Chemistry (4)
A continuation of 141A, this course applies the structure-reactivity,
spectroscopy, and electronic theories introduced in 141A to organic reactions.
Prerequisite: Chem. 141A. (Note: Students may not receive credit
for both Chem. 141B and Chem. 140B.) (W)
141C. Organic Chemistry (4)
A continuation of 141A-B, this course treats selected topics such as carbon-metal
bonds, organometallic chemistry, electrophilic reactions, free radical
reactions, alkane chemistry, polymerization, molecular orbital theory
and electrocyclic reactions, photochemistry, unstable intermediates such
as carbenes, benzyne, etc., and metal oxidation reactions, and an introduction
to carbohydrate and protein chemistry. Prerequisite: Chem. 141B.
(Note: Students may not receive credit for both Chem. 141C and Chem. 140C.)
(S)
142. Natural Products Chemistry (4)
An outline of the chemistry of terpenes, steroids, alkaloids, and plant
phenols developed on the basis of modern biogenetic theory. Special emphasis
will be given to biologically active substances such as hormones and antibiotics.
Prerequisites: Chem. 140A-B-C, or 141A-B-C. (May not be offered
every year.)
143A. Organic Chemistry Laboratory (4)
Introduction to laboratory techniques needed in organic chemistry. Stresses
physical methods including separation and purification, spectroscopy,
product analysis and effects of reaction conditions. Prerequisites:
Chem. 6BL, Chem. 141A or Chem. 140A. (Note: Students may not receive
credit for both Chem.143A and Chem. 143AM.) A materials fee is required
for this course. (F,W,S)
143AM. Majors Organic Chemistry Laboratory (4)
An organic chemistry laboratory intended for chemistry majors only. It
is similar to Chem. 143A, but with emphasis on instrumental methods of
product identification, separation, and analysis. Prerequisites: Chem.
6BL; Chem. 141A. (Note: Students may not receive credit for both Chem.
143AM and Chem. 143A.) A materials fee is required for this course. (W)
143B. Organic Chemistry Laboratory (4)
Continuation of 143AM or 143A, emphasizing synthetic methods of organic
chemistry for chemistry majors only. Prerequisites: Chem. 143A; 141B
or 140B (may be taken concurrently). A materials fee is required for
this course. (W,S)
143C. Organic Laboratory (5)
Identification of unknown organic compounds by a combination of chemical
and physical techniques for chemistry majors only. Prerequisites: Chem.
6CL, 143A, 141C (may be taken concurrently); 143B suggested. A materials
fee is required for this course. (F)
144. Synthesis of Complex Molecules (4)
This course discusses planning economic routes for the synthesis of complex
organic molecules. The uses of specific reagents and protecting groups
will be outlined as well as the control of stereochemistry during a synthesis.
Examples will be selected from the recent literature. Prerequisites:
Chem. 148 or 248. (May not be offered every year.)
145. Structure and Properties of Organic Molecules (4)
Introduction to the measurement and theoretical correlation of the physical
properties of organic molecules. Topics covered include molecular geometry,
molecular-orbital theory, orbital hybridization, aromaticity, chemical
reactivity, stereochemistry, infrared and electronic spectra, photochemistry,
and nuclear magnetic resonance. Prerequisites: Chem. 140ABC or 141ABC
or the equivalent.
147. Mechanisms of Organic Reactions (4)
A qualitative approach to the mechanisms of various organic reactions;
substitutions, additions, eliminations, condensations, rearrangements,
oxidations, reductions, free-radical reactions, and photochemistry. Includes
considerations of molecular structure and reactivity, synthetic methods,
spectroscopic tools, and stereochemistry. The topics emphasized will vary
from year to year. This is the first quarter of the advanced organic chemistry
sequence. Prerequisite: Chem. 140C or 141C. (May not be offered
every year.)
148. Synthetic Methods in Organic Chemistry (4)
A survey of reactions of particular utility in the organic laboratory.
Emphasis is on methods of preparation of carbon-carbon bonds and oxidation
reduction sequences. Prerequisite: Chem. 140C or 141C or consent of
instructor. (May not be offered every year.)
149A. Environmental Chemistry (4)
The chemical basis of air and water pollution, chlorofluorocarbons and
the ozone hole, the environmental impact of radioactive waste disposal,
mineral resource usage, and nuclear energy. Prerequisites: Chem. 6A-B-C.
(F)
149B. Environmental Chemistry (4)
Agricultural productivity, biological impact on the environment, deforestation,
environmental disasters (fires, nuclear winter, and volcanoes), and organic
waste handling. Prerequisite: Chem. 149A. (W)
153. Topics in Biophysics/Photobiology (4)
Basic principles of photobiology and photochemistry. Photochemical mechanisms
in photosynthesis. Photoreceptor pigment systems and photobiological control
mechanisms in living organisms. Prerequisite: upper-division standing
in biology, chemistry, or physics, or consent of the instructor. (Same
as BIBC 153, Phys. 153.)
167. Biochemistry of Lipid Diseases (4)
The central theme of this course will be to develop a broad understanding
of the basic biochemical aspects of lipid metabolism, the regulation of
lipid metabolism and application to the treatment of specific human diseases.
Prerequisite: biochemistry. (May not be offered every year.)
170. Cosmochemistry (4)
Composition of stars, of planets, of meteorites, and the earth and moon.
Nuclear stability rules and isotopic composition of the elements. Chemical
properties of solar matter. Origin of the elements and of the solar system
Prerequisite: general chemistry sequence.
171. Nuclear and Radiochemistry (4)
Radioactive decay, stability systematics, neutron activation, nuclear
reactions. Szilard-Chalmers reactions, hot-atom chemistry, radiation chemistry,
effects of ionizing radiation. Prerequisite: general chemistry sequence.
173. Atmospheric Chemistry (4)
Chemical principles applied to the study of atmospheres. Atmospheric photochemistry,
radical reactions, chemical lifetime determinations, acid rain, greenhouse
effects, ozone cycle, and evolution are discussed. Prerequisites: Chem.
6A-6C. (S)
185. Introduction to Computational Chemistry (4)
This course in computational methods builds on a background in mathematics
and physical chemistry. After a brief introduction and background in computational
theory, topics will include molecular mechanics, semi-empirical methods,
and ab initio-based methods of increasing elaboration. Emphasis will be
on applications and reliability. Prerequisites: Chem. 126 or 133 and
Math. 20C. (May not be offered every year.)
190. Mathematical Methods of Chemistry (4)
Applied mathematics useful for kinetics, thermodynamics, statistical mechanics
and quantum mechanics. Topics include ordinary and partial differential
equations, special functions, probability and statistics, vector functions
and operators, linear algebra, and group theory. Prerequisites: general
chemistry, one year of calculus. (May not be offered every year.)
195. Methods of Teaching Chemistry (4)
An introduction to teaching chemistry. Students are required to attend
a weekly class on methods of teaching chemistry, and will teach a discussion
section of one of the lower-division chemistry courses. Attendance at
lecture of the lower-division course in which the student is participating
is required. (P/NP grades only.) Prerequisite: consent of instructor.
(F,W,S)
196. Reading and Research in Chemical Education (2 or 4)
Independent literature or classroom research by arrangement with, and
under the direction of, a member of the Deparment of Chemistry faculty.
Students must register on a P/NP basis. Prerequisites: upper-division
standing, 2.5 minimum GPA, consent of instructor and department.
199. Reading and Research (2 or 4)
Independent literature or laboratory research by arrangement with, and
under the direction of, a member of the Department of Chemistry faculty.
Students must register on a P/NP basis. Prerequisites: upper-division
standing, 2.5 minimum GPA, consent of instructor and department. (F,W,S)
Graduate
206. Topics in Biophysics and Physical Biochemistry (4)
Selection of topics of current interest. Examples: primary processes of
photosynthesis; membrane biophysics; applications of physical methods
to problems in biology and chemistry, e.g., magnetic resonance, x-ray
diffraction, fluctuation spectroscopy, optical techniques (fluorescence,
optical rotary dispersion, circular dichroism). Topics may vary from year
to year. Prerequisite: consent of instructor. (W)
207. Modern NMR Methods (4)
Treats varied pulse sequences, one- and two-dimensional methods, interpretation
of relaxation rates, spin-decoupling, multiple quantum filtering, and
solvent suppression with application to liquid crystals, membranes, small
molecules, proteins, and nucleic acids. (May not be offered every year.)
208. Modern Methods in Protein NMR (4)
This course covers modern methods in protein NMR including multinuclear,
multidimensional (2-, 3-, and 4D) and gradient enhanced spectroscopy.
Experiments covered include, but are not limited to, 1H-15N HSQC, 15N
edited Tocsy and Noesy, HDDH-Tocsy and 1H-15N-13C correlated experiments.
Students will be able to write complete pulse sequences from the primary
literature for implementation on a Bruker spectrometer by the end of the
quarter. Prerequisite: Chem. 207. (May not be offered every year.)
(S)
210. Biotechnology and Drug Discovery (2)
This seminar course will explore how the biotechnology and pharmaceutical
industry utilizes chemistry, biochemistry, and molecular biology to discover
and develop today's pharmaceutical agents (drugs): process of lead
discovery, development, animal toxicity, clinical trials, manufacturing,
quality assurance, regulatory affairs, etc. Guest lecturers will be from
the local biotechnology industry. Prerequisite: biochemistry background
preferred. (S)
211. Metabolic Biochemistry (4)
A comprehensive course in biochemistry emphasizing metabolic and human
biochemistry. Prerequisites: physical and organic chemistry; graduate-student
standing. (F)
212. Biochemistry of Growth Regulation and Oncogenesis (4)
An introduction to the biochemistry of growth regulation and oncogenesis.
Topics include: tryosine protein kinases; growth factor receptors; control
of cell proliferation; transformation by papovaviruses and retroviruses.
Designed for graduate students, but suitable for undergraduates with consent
of instructor. Prerequisite: biochemistry, molecular biology, or equivalent.
(May not be offered every year.)
213. Chemistry of Macromolecules (4)
A discussion of the structural principles governing biological macromolecules,
the techniques used in their study, and how their functional properties
depend on three-dimensional structure. Prerequisites: elementary physical
and organic chemistry. (May not be offered every year.)
214. Molecular and Cellular Biochemistry (4)
This course represents a continuation of 114C, or an introductory course
for first- and second-year graduate students, and covers topics in molecular
and cellular biochemistry. Emphasis will be placed on contemporary approaches
to the isolation and characterization of mammalian genes and proteins,
and molecular genetic approaches to understanding eukaryotic development
and human disease. Prerequisite: Chem. 114A-C or consent of instructor.
(May not be offered every year.)
215. Modeling Biological Macromolecules (4)
Use of computer graphics and modeling methods in the study of biological
macromolecules. The course will cover basic methods and techniques. The
objective is to provide a good working knowledge of the critical features
of the methods and to provide a foundation for further study for those
who wish to pursue these methods as research topics. Prerequisite:
Chem. 114A or equivalent. (May not be offered every year.)
216. Chemistry of Enzyme Catalyzed Reactions (4)
A discussion of the chemistry of representative enzyme catalyzed reactions
is presented. Enzyme reaction mechanisms and coenzyme chemistry are emphasized.
Prerequisite: organic chemistry. (May not be offered every year.)
217. Immunology (3)
Graduate students will explore topics in specialized areas of immunochemistry
and cellular immunology, antigenic and molecular structure of immunoglobulin
molecules; antigenantibody interactions; cellular events in the humoral
and cellular immune responses; translation immunology. Prerequisite:
consent of instructor. (F)
218. Macromolecular Biochemistry (4)
A comprehensive course in biochemistry emphasizing structural biochemistry.
Prerequisites: physical and organic chemistry; graduate-student standing.
(F)
219A-B-C. Special Topics in Biochemistry (4-4-4)
This special topics course is designed for first-year graduate students
in biochemistry. Topics presented in recent years have included protein
processing, the chemical modification of proteins, the biosynthesis and
function of glycoproteins, lipid biochemistry and membrane structure,
and bioenergetics. Prerequisites: undergraduate courses in biochemistry.
(May not be offered every year.)
221. Signal Transduction (4)
The aim of this course is to develop an appreciation for a variety of
topics in signal transduction. We will discuss several historical developments
while the focus will be on current issues. Both experimental approaches
and results will be included in our discussions. Topics may vary from
year to year. Prerequisites: biochemistry and molecular biology. (May
not be offered every year.)
222. Structure and Bonding of Solids (4)
Key concepts in the atomic structure and bonding of solids such as metals,
ceramics, and semiconductors. Symmetry operations, point groups, lattice
types, space groups, simple and complex inorganic compounds, structure/property
comparisons, structure determination with X-ray diffraction. Ionic, covalent,
metallic bonding compared with physical properties. Atomic and molecular
orbitals, bands versus bonds, free electron theory.
223. Organometallic Chemistry (4)
A survey of this field from a synthetic and mechanistic viewpoint. Reactivity
patterns for both main group and transition element organometallic compounds
will be discussed and organized to periodic trends. (May not be offered
every year.)
224. Spectroscopic Techniques (4)
Application of physical techniques to the elucidation of the structure
of inorganic complex ions and organometallic compounds. Topics covered
include group theory, and its application to vibrational, magnetic resonance
and Raman spectroscopy. (May not be offered every year.)
225. Bioinorganic Chemistry (4)
The role of metal ions in biological systems, with emphasis on transition
metal ions in enzymes that transfer electrons, bind oxygen, and fix nitrogen.
Also included are metal complexes in medicine, toxicity, and metal ion
storage and transport. (May not be offered every year.)
226. Mechanistic Aspects of Catalytic Reactions (4)
Mechanisms of substitution and electron transfer reaction of inorganic
complexes will be examined from an experimental point of view. A quantitative
treatment of rate laws, the steady state approximation and multistep mechanisms
of reactions that are catalyzed by soluble transition metal complexes.
(May not be offered every year.)
227. Seminar in Inorganic Chemistry (2)
Seminars presented by faculty and students on topics of current interest
in inorganic chemistry, including areas such as bioinorganic, organometallic
and physical-inorganic chemistry. The course is designed to promote a
critical evaluation of the available data in specialized areas of inorganic
chemistry. Each quarter three or four different topics will be discussed.
Prerequisite: graduate standing or consent of instructor.
228. Solid State Chemistry (4)
Survey of the chemistry of semiconductors, superconductors, molecular
magnetic materials, zeolites, fast ion conductors, electronically conducting
polymers, and ceramics. Synthetic techniques such as molecular precursor
design, the sol-gel process, electrosynthesis, and high-temperature thermolysis
will be covered. (May not be offered every year.)
229. Special Topics in Inorganic Chemistry (2-4)
(May not be offered every year.)
230. Quantum Mechanics (4)
Concepts and mathematical formalism that are useful for problems of chemical
interest: states, representations, operators, eigenvalues and eigenfunctions,
time evolution, observables, and measurements. Time-
independent perturbation theory. Prerequisites: Chem. 133 or equivalent;
Math. 20D or equivalent; Chem. 190 may be taken concurrently. (May
not be offered every year.)
231. Chemical Kinetics and Molecular Reaction Dynamics (4)
Classical kinetics, transition state theory, unimolecular decomposition,
potential energy surfaces; scattering processes and photodissociation
processes. Prerequisite: Chem. 230. (May not be offered ever year.)
232. Statistical Mechanics of Chemical Systems (4)
Equilibrium statistical mechanics, distribution functions, and partition
functions. Boltzman, Bose, and Fermi statistics. The different ensembles;
ensemble averages and QM expectation values; derivation of thermodynamic
properties of simple systems. Prerequisites: Chem. 133, 131 and 132,
or equivalent. (May not be offered every year.)
233. Nonequilibrium Statistical Mechanics (4)
Linear response theory, time correlation functions,
and spectral densities. Schmoluchowski, Langevin,
and Fokker-Planck equations; nonlinear behavior. Newtonian and Brownian
molecular dynamics calculations. Prerequisite: Chem. 232. (May
not be offered every year.)
234. Thermodynamics (4)
Thermodynamics of chemical systems; the three laws, with emphasis on the
formal structure of thermodynamics. Chemical equilibrium, stability theory,
heterogeneous equilibrium, solutions. Prerequisites: Chem. 131, 132
or equivalent. (May not be offered every year.)
235. Molecular Spectroscopy (4)
Time-dependent behavior of systems; interaction of matter with light;
selection rule. Radiative and nonradiative processes, coherent phenomena
and the density matrices. Instrumentation, measurement, and interpretation.
Prerequisites: Chem. 133 or equivalent; Math. 20D or Chem. 190/290.
(May not be offered every year.)
236. Atherosclerosis (2)
This multidisciplinary course integrates the studies of the pathogenesis
of atherosclerosis, with emphasis on lipoprotein metabolism, and the cellular
and biochemical mechanisms of lesion development. Two-hour lectures. Same
as Medicine 236. Prerequisite: biochemistry. (May not be offered
every year.)
237. Essentials of Glycobiology (2)
Advanced elective for graduate/medical students who have had core courses
in cell biology or biochemistry. Expert faculty will present a coordinated
overview of the field of glycobiology, which explores the structure, synthesis,
and functions of sugar chains in biological systems. (May not be offered
every year.)
238. Current Topics in Physical Chemistry (4)
Critical reading of current literature; training and practice in presenting
oral reports, writing scientific papers and proposals. (May not be offered
every year.)
239. Special Topics in Chemical Physics (4)
Topics of special interest will be presented. Examples include NMR, solid-state
chemistry, phase transitions, stochastic processes, scattering theory,
nonequilibrium processes, tensor transformations, and advanced topics
in statistical mechanics, thermodynamics, and chemical kinetics. (May
not be offered every year.)
240. Electrochemistry (4)
Application of electrochemical techniques to chemistry research. Basic
electrochemical theory and instrumentation: the diffusion equations, controlled
potential, and current methods. Electro-chemical kinetics, Butler-Volmer,
Marcus-Hush theories, preparative electrochemistry, analytical electrochemistry,
solid and polymer electrolytes, semiconductor photoelectrochemistry. (May
not be offered every year.)
242. Natural Products Chemistry (4)
An outline of the chemistry of terpenes, steroids, alkaloids, and plant
phenols developed on the basis of modern biogenetic theory. Special emphasis
will be given to biologically active substances such as hormones and antibiotics.
Prerequisites: Chem. 140A-B-C or 141A-B-C.
244. Synthesis of Complex Molecules (4)
This course discusses planning economic routes for the synthesis of complex
organic molecules. The uses of specific reagents and protecting groups
will be outlined as well as the control of stereochemistry during a synthesis.
Examples will be selected from the recent literature. Prerequisite:
Chem. 148 or 248.
245. Structure and Properties of Organic Molecules (4)
Introduction to the measurement and theoretical correlation of the physical
properties of organic molecules. Topics covered include molecular geometry,
molecular-orbital theory, orbital hybridization, aromaticity, chemical
reactivity, stereochemistry, infrared and electronic spectra, photochemistry,
and nuclear magnetic resonance. Prerequisite: Chem. 140ABC or 141ABC
or the equivalent.
246. Kinetics and Mechanism (4)
Methodology of mechanistic organic chemistry: integration of rate expressions,
determination of rate constants, transition state theory; catalysis, kinetic
orders, isotope effects, substitute effects, solvent effects, linear free
energy relationship; product studies, stereochemistry; reactive intermediates;
rapid reactions. (May not be offered every year.)
247. Mechanisms of Organic Reactions (4)
A qualitative approach to the mechanism of various organic reactions;
substitutions, additions, eliminations, condensations, rearrangements,
oxidations, reductions, free-radical reactions, and photochemistry. Includes
considerations of molecular structure and reactivity, synthetic methods,
spectroscopic tools, and stereochemistry. The topics emphasized will vary
from year to year. This is the first quarter of the graduate organic chemistry
sequence. Prerequisite: Chem. 141C.
248. Synthetic Methods in Organic Chemistry (4)
A survey of reactions of particular utility in the organic laboratory.
Emphasis is on methods of preparation of carbon-carbon bonds and oxidation-reduction
sequences. Prerequisite: Chem. 141C or consent of instructor.
249. Special Topics in Organic Chemistry (2-4)
(May not be offered every year.)
250. Seminar in Chemistry (2)
Regularly scheduled seminars by first-year graduate students provide opportunities
for practice in seminar delivery and for the exploration of topics of
general interest. (S/U grades only.) (S)
251. Research Conference (2)
Group discussion of research activities and progress of the group members.
Prerequisite: consent of instructor. (S/U grades only.) (F,W,S)
262. Inorganic Chemistry and NMR (4)
A survey of inorganic chemistry to prepare for graduate research in the
field, including a detailed introduction to nuclear magnetic resonance
(NMR), followed by applications of NMR to structural and mechanistic problems
in inorganic chemistry.
267. Biochemistry of Lipid and Lipoprotein Diseases (4)
The central theme of this course will be to develop a broad understanding
of the basic biochemical aspects of lipid metabolism, the regulation of
lipid metabolism, and application to the treatment of specific human diseases.
(May not be offered every year.)
270A-B-C. Current Topics in EnvironmentalChemistry (2-2-2)
Formal lecture series on the current topics in the field of environmental
chemistry. Emphasis is on current research topics in atmospheric, oceanic,
and geological environments. Prerequisite: consent of instructor. (May
not be offered every year.)
285. Introduction to Computational Chemistry (4)
This course in computational methods builds on a background in mathematics
and physical chemistry. After a brief introduction and background in computational
theory, topics will include molecular mechanics, semi-empirical methods,
and ab initio-based methods of increasing elaboration. Emphasis will be
on applications and reliability. Prerequisites: Chem. 126 or 133 and
Math. 20C. (May not be offered every year.)
290. Mathematical Methods in Chemistry I (4)
Applied mathematics useful in kinetics, spectroscopy, thermodynamics,
statistical mechanics, and quantum mechanics; ordinary and partial differential
equations, vector spaces, operators, linear algebra, numerical analysis.
Prerequisites: general chemistry, calculus. (May not be offered
every year.)
293. Cosmochemistry Seminar (2)
Formal seminars or informal sessions on topics of current interest in
cosmochemistry as presented by visiting lecturers, local researchers,
or students. Prerequisite: advanced graduate-student standing.
(S/U grades only.)
294. Organic Chemistry Seminar (2)
Formal seminars or informal puzzle sessions on topics of current interest
in organic chemistry, as presented by visiting lecturers, local researchers,
or students. Prerequisite: advanced graduate-student standing.
(S/U grades only.) (F,W,S)
295. Biochemistry Seminar (2)
Formal seminars or informal puzzle sessions on topics of current interest
in biochemistry, as presented by visiting lecturers, local researchers,
or students. Prerequisite: advanced graduate-student standing. (S/U
grades only.)
296. Chemical Physics Seminar (2)
Formal seminars or informal sessions on topics of current interest in
chemical physics as presented by visiting lecturers, local researchers,
or students. Prerequisite: advanced graduate-student standing.
(S/U grades only.) (F,W,S)
297. Experimental Methods in Chemistry (4)
Experimental methods and techniques involved in chemical research are
introduced. Hands-on experience provides training for careers in industrial
research and for future thesis research. Prerequisite: graduate standing.
298. Special Study in Chemistry (1-4)
Reading and laboratory study of special topics under the direction of
a faculty member. Exact subject matter to be arranged in individual cases.
(S/U grades only.) Credit is limited to four units per quarter. (F,W,S)
299. Research in Chemistry (1-12)
Prerequisites: graduate standing and consent of instructor. (S/U
grades only.) (F,W,S)
500. Teaching in Chemistry (4)
A doctoral student in chemistry is required to assist in teaching undergraduate
chemistry courses. One meeting per week with instructor, one or more meetings
per week with assigned class sections or laboratories, and attendance
at the lecture of the undergraduate course in which he or she is participating.
Prerequisites: graduate standing and consent of instructor. (S/U
grades only.) (F,W,S)