Molecular
Pathology
Courses
For course descriptions not found in the 2006-2007 General Catalog,
please contact the department for more information.
PATH 208G. Human
Disease (8) An integrated
consideration of the general principles of pathology and microbiology,
epidemiology, and medical therapeutics of the important diseases.
An
example of their application to a specific organ system will be included.
(Not offered in 2006-07.)
PATH 220. Mechanisms
of Neurological Disease (4) This
course will explore the molecular pathology associated with various
diseases other than cancer. Emphasis will be placed on understanding
the abberant cellular processes, caused by mutation or environmental
factors, that are associated with the disease state. Cardiovascular,
neurological, immunological, and other diseases will be investigated.
PATH 221. Molecular Pathology of Cancer (4) The
purpose of this course is to present exciting new developments in molecular
carcinogenesis, with particular emphasis on oncogene expression and
functions of oncogenic proteins. The relevance of molecular mechanisms
for understanding human cancer will be discussed.
PATH 222. Microbial Pathogenesis (4) Topics
covered in this course include molecular and cellular mechanisms of
viral, bacterial, and protozoan pathogenesis. Host response and microbial
mechanisms of host defense will also be discussed. Sessions will consist
of faculty and student presentations of current literature.
PATH 223. Mouse
Models of Human Disease (2)
This course provides an overview of the use of mouse models in biomedical
research. Sessions will cover general mouse biology, genetics, and
technologies for generating mutant mice; and will focus on model
selection, methodological approaches, data interpretation, experimental
design,
and ethics of animal research. Student participation and discussion
will be encouraged. Prerequisite: graduate standing or consent of
instructor.
PATH 225. Molecular
Pathology Research Seminars (2)
This course presents developments in cellular and molecular pathology
research. Both faculty and students actively participate in the individual
sessions. All students are required to give one to two formal presentations
(under faculty supervision) during the year. The relevance of molecular
mechanisms for understanding human disease will be discussed. Prerequisite:
consent of instructor.
PATH 230G. Molecular Biology of the Cell (6) This
course offers a concise overview of the biochemical basis of gene expression
and of diverse signal transduction pathways, and integrates this background
in the context of cellular processes such as cell division, development,
cell-cell interactions, and inflammation. This course will highlight
recent discoveries in cellular and molecular biology and will highlight
human diseases that result from inappropriate regulation of cellular
processes.
PATH 231. Modern Methods in Molecular and Cell Biology (4) This
course presents key concepts and methodologies used in cellular and
molecular pathology research. Topics include protein purification,
biochemical characterization, identification of post-translational
modifications, DNA/protein microinjection, immunofluorescence, digital
imaging, electron microscopy, stem cell culture, gene/promoter analysis,
protein-protein interaction analysis using the yeast 2-hybrid system,
transgenic and knockout mouse construction, analysis of bacterial
virulence factors, and genomic/proteinomic approaches to disease
analysis.
PATH 232. Statistical Methods and Experimental Design
This course will emphasize the relationships between experimental design,
statistical methods, and biomedical research. The content of the course
will include basic issues in experimental design and commonly used statistical
methods. The assumptions behind the statistical tests, their appropriate
use, and examples of misuse will be discussed.
PATH 296. Directed Reading (1-4) Reading
and laboratory study of special topics under the direction of a faculty
member. Exact subject matter to be arranged in individual cases.
PATH 299. Independent Study or Research (1-12) Independent
study or research.
SOM 213. Histology (2) This course teaches
the structural basis of normal and abnormal function at the cellular
and tissue levels. Emphasis is based on microscopic study conducted
in small laboratory groups under close faculty supervision.
SPPS 215. Human Disease (3) This introduction to human disease
includes etiology and mechanisms of common disease states and integrates
pathology with previous core
curriculum. The focus will be to understand disease processes and
the dynamics of changes related to drug thearapy. Our goal is to
give the student an overview of the illnesses and disorders of human
organs, systems and functions, in other words, human disease, with
the hope that this background will lead the students to clinical
understanding of patients and future insight into the pathogenesis
of disease and new treatments. This course will include general pathology
and system based pathology, taught in lecture, case discussion, and
lab format.
Molecular Pathology Courses
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