Chemistry and Biochemistry
Courses
Lower-Division
4. Basic Chemistry (4) Chemistry 4 is a one-quarter
course for science majors with insufficient preparation to start the
Chem. 6 sequence. Emphasis is on learning how to solve quantitative
problems. Topics include nomenclature, stoichiometry, and the periodic
table. Cannot be taken for credit after any other chemistry course.
Includes a combined laboratory and discussion-recitation each week.
Prerequisite: Math. 4C. A materials fee is required for this course.
Cannot be taken for credit after any other chemistry course. (F)
6A. General Chemistry (4) First quarter of
a three-quarter sequence intended for science and engineering majors.
Topics include: stoichiometry, gas laws, bonding, atomic theory, quantum
theory, and thermochemistry. Three hours lecture, one hour recitation.
Prerequisites: proficiency in high school chemistry or physics. Math
10A (may be taken concurrently). (F,W,S)
6AH. Honors General Chemistry (4) First quarter
of a three-quarter honors sequence intended for well-prepared science
and engineering majors. Topics include: stoichiometry, gas laws, bonding,
atomic theory, quantum theory, and thermochemistry. Three hours lecture,
one hour recitation. Prerequisites: proficiency in high school chemistry,
physics and mathematics. Concurrent enrollment in Math. 20A or higher
level calculus required. (F)
6B. General Chemistry (4) Second quarter of
a three-quarter sequence intended for science and engineering majors.
Topics include: molecular geometry, condensed phases and solutions,
chemical equilibrium, acids and bases and thermodynamics. Three hours
lecture, one hour recitation. Prerequisites: Chem. 6A; Math. 20A
or 10A. (F,W,S)
6BH. Honors General Chemistry (4) Second quarter
of a three-quarter honors sequence intended for well-prepared science
and engineering majors. Topics include: molecular geometry, condensed
phases and solutions, chemical equilibrium, acids and bases and thermodynamics.
Three hours lecture, one hour recitation. Prerequisites: Chem. 6AH;
Math. 20A. (W)
6BL. Introductory Inorganic Chemistry Laboratory (3) Introduction
to experimental procedures used in synthetic, analytical, and physical
chemistry. Prerequisite: Chem. 6A, 6B. If 6BL is a requirement for
your major, it should be taken concurrently with 6C. A materials fee is
required for this course. (F,W,S)
6C. General Chemistry (4) Third quarter of a
three-quarter sequence intended for science and engineering majors. Topics
include: electrochemistry, kinetics, coordination chemistry, nuclear chemistry,
and an introduction to organic and biochemistry. Three hours lecture,
one hour recitation. Prerequisite: Chem. 6B; Chem. 6BL may be taken
concurrently. (F,W,S)
6CH. Honors General Chemistry (4) Third quarter
of a three-quarter honors sequence intended for well-prepared science
and engineering majors. Topics include: electrochemistry, kinetics,
coordination chemistry, nuclear chemistry, and an introduction to organic
and biochemistry. Three hours lecture, one hour recitation. Prerequisites:
Chem. 6BH; Math. 20B. Chem. 6BL may be taken concurrently. (S)
6CL. Introductory Analytical Chemistry (4) A
laboratory course with emphasis on safe, accurate, and precise experimental
techniques in chemistry, including quantitative analysis and instrumental
methods, usually taken concurrently with Chem. 6C, but required for
only certain majors. Prerequisite: Chem. 6BL. A materials fee is
required for this course. (F,W,S)
11. The Periodic Table (4) Introduction to
the material world of atoms and small inorganic molecules. Intended
for nonscience majors. Can be skipped by students with good knowledge
of high school chemistry. Cannot be taken for credit after any other
general chemistry course. (F)
12. Molecules and Reactions (4) Introduction
to molecular bonding and structure and chemical reactions, including
organic molecules and synthetic polymers. Intended for nonscience majors.
Prerequisite: Chem. 11 or good knowledge of high school chemistry.
Cannot be taken for credit after any organic chemistry course. (W)
13. Chemistry of Life (4) Introduction to
biochemistry for nonscience majors. Prerequisite: Chem. 12. Cannot
be taken for credit after any biochemistry course. (S)
15. Chemistry of the Universe (4) This is
a one-quarter, nonmathematical chemistry course for nonscience majors
covering the origin of the universe, the elements, and the formation
of the solar system. The evolution of the Earths atmosphere, hydrosphere,
geosphere, and biosphere will be covered, as well as contemporary problems
in environmental chemistry. Cannot be taken for credit after any other
chemistry course.
87. Freshman Seminar in Chemistry and Biochemistry (1) This
seminar will present topics in chemistry at a level appropriate for
first-year students.
90. Undergraduate Seminar (1) The seminar
will focus on a variety of issues and special areas in the field of
chemistry.
91. Undergraduate Honors Seminar (1) A seminar
intended for exposing undergraduate students, especially freshmen and
sophomores, to exciting research programs conducted by the faculty.
Enrollment is limited.
92. Undergraduate Pharmacology Seminar (1) Selected
topics in pharmacology and toxicology.
Upper-Division
105A. Physical Chemistry Laboratory (5) Laboratory
course in experimental physical chemistry. Prerequisites: Chem. 6CL
and Phys. 2CL or equivalent, Chem. 131 or 133 or 126 or 127. A materials
fee is required for this course. (F,W,S)
105B. Physical Chemistry Laboratory (4) Laboratory
course in experimental physical chemistry. Prerequisites: Chem. 105A
and 133. A materials fee is required for this course. (F,W,S)
106. Instrumental Analysis Laboratory (4) Instrumental
methods for analytical chemistry emphasizing physical principles underlying
both the instruments and the analytical methods. Prerequisite: Chem.
105A. A materials fee is required for this course. (W)
107. Synthetic Macromolecules (4) The organic
and physical chemistry of high polymers with emphasis on synthesis,
structure, characterization, and properties. Polymers as materials are
important as films, fibers, and elastomers. They play an ever-increasing
role in science, technology, and medicine. Prerequisites: Chem. 126
or 131 and 140B or 141B. (May not be offered every year.)
112A. Molecular Biochemistry Laboratory (6) The
application of techniques, including electrophoresis, peptide mapping
and sequencing, affinity chromatography, amino acid analysis, gas-liquid
chromatography, and enzyme functions and the chemistry of lipids, carbohydrates,
and nucleic acids. Prerequisites: Chem. 140A-B-C or 141A-B-C, 143A-B,
114A-B. (Some of these courses may be taken concurrently.) (Note:
Students may not receive credit for both Chem. 112A and BIBC 103.) A
materials fee is required for this course. (W)
112B. Molecular Biochemistry Laboratory (6) This
laboratory will introduce the students to the tools of molecular biology
and will involve experiments with recombinant DNA techniques. Prerequisites:
Chem. 114A-B, Chem. 114C (may be taken concurrently); Chem. 143A and
143B. (Note: Students may not receive credit for both Chem. 112B
and BIMM 101.) A materials fee is required for this course. (S)
113. Chemistry of Biological Macromolecules (4) A
discussion of the structural principles governing biological macromolecules,
the techniques used in their study, and how their functional properties
depend on three-dimensional structure. Prerequisites: elementary
organic and physical chemistry. (May not be offered every year.)
114A. Biochemical Structure and Function (4) Introduction
to biochemistry from a structural and functional viewpoint. Prerequisite:
elementary organic chemistry (Chem. 140A or equivalent). (Note: Students
may not receive credit for both Chem. 114A and BIBC 100.) (F)
114B. Biochemical Energetics and Metabolism (4) This
course is an introduction to the metabolic reactions in the cell which
produce and utilize energy. The course material will include energy-producing
pathways: glycolysis, Krebs cycle, oxidative phosphorylation, fatty-acid
oxidation. Biosynthesisamino acids, lipids, carbohydrates, purines,
pyrimidines, proteins, nucleic acids. Prerequisite: Chem. 114A.
(Note: Students may not receive credit for both Chem. 114B and BIBC
102) (W)
114C. Biosynthesis of Macromolecules (4) This
course is a continuation of the introduction to biochemistry courses
(114A and 114B). This quarter reviews the mechanisms of biosynthesis
of macromoleculesparticularly proteins and nucleic acids. Emphasis
will be placed on how these processes are controlled and integrated
with the metabolism of the cell. Prerequisite: Chem. 114B. (Note:
Students may not receive credit for both Chem. 114C and BIMM 100.) (S)
114D. Molecular and Cellular Biochemistry (4) This
course represents a continuation of 114C, or an introductory course
for first- and second-year graduate students, and covers topics in molecular
and cellular biochemistry. Emphasis will be placed on contemporary approaches
to the isolation and characterization of mammalian genes and proteins,
and molecular genetic approaches to understanding eukaryotic development
and human disease. Prerequisite: Chem. 114A-C or consent of instructor.
(May not be offered every year.)
115. Modeling Biological Macromolecules (4) Use
of computer graphics and modeling methods in the study of biological
macromolecules. The course will cover basic methods and techniques.
The objective is to provide a good working knowledge of the critical
features of the methods and to provide a foundation for further study
for those who wish to pursue these methods as research topics. Prerequisite:
Chem. 114A or equivalent. (May not be offered every year.)
116. Chemistry of Enzyme Catalyzed Reactions (4) A
discussion of the chemistry of representative enzyme catalyzed reactions
is presented. Enzyme reaction mechanisms and their relation to enzyme
structure are emphasized. Prerequisites: elementary physical chemistry,
organic chemistry, and biochemistry. (May not be offered every year.)
117. Biochemistry of Human Disease (4) An
advanced course in biochemistry which will deal primarily with the molecular
basis of human disorders. Prerequisite: elementary biochemistry.
(May not be offered every year.)
118. Pharmacology and Toxicology (4) A survey
of the biochemical action of drugs and toxins as well as their absorption
and excretion. Prerequisites: Chem. 141A-B-C (or Chem. 140ABC), Chem.
114A-B-C and admission to Pharmacological Chemistry major, or consent
of instructor.
120A. Inorganic Chemistry (4) The chemistry
of the main group elements is presented in terms of atomic structure,
ionic and covalent bonding. Structural theory involving s, p, and unfilled
d orbitals is described. Thermodynamic and spectroscopic criteria for
structure and stability of compounds are presented and chemical reactions
of main group elements discussed in terms of molecular structure and
reactivity. Prerequisites: a general chemistry course. Chem. 140A
or 141A or equivalent course is recommended. (F)
120B. Inorganic Chemistry (4) A continuation
of the discussion of structure, bonding, and reactivity with emphasis
on transition metals and other elements using filled d orbitals to form
bonds. Coordination chemistry is discussed in terms of valence bond,
crystal field, and molecular orbital theory. The properties and reactivities
of transition metal complexes including organometallic compounds are
discussed. Prerequisite: Chem. 120A. (W)
122. Biochemical Evolution (4) This course
emphasizes the chemical aspects of evolution, including the origin of
living systems on earth, primitive energy acquisition devices, the coupling
of information storage and replication catalysis, protein evolution,
and the biochemical unity and diversity of extant organisms. Prerequisites:
organic chemistry and introductory biochemistry. (May not be offered
every year.)
123. Advanced Inorganic Chemistry Laboratory (4) Synthesis,
analysis, and physical characterization of inorganic chemical compounds.
Prerequisite: Chem. 120A, 120B, 143A, and 143B. A materials fee is
required for this course.
124. Bioinorganic Chemistry (4) The role of
metal ions in biological systems, with emphasis on transition metal
ions in enzymes that transfer electrons, bind oxygen, and fix nitrogen.
Also included are metal complexes in medicine, toxicity, and metal ion
storage and transport. Prerequisites: Chem. 6A-B-C, 114A; or equivalent.
(May not be offered every year.)
126. Physical Chemistry (4) An introduction
to physical chemistry with emphasis on biochemical and environmental
applications. Quantum mechanics, atomic and molecular structure, spectroscopy.
Prerequisites: Chem. 6C, Math. 20D or 21D, and Phys. 2D; or consent
of instructor. (F)
127. Physical Chemistry (4) An introduction
to physical chemistry with emphasis on biochemical and environmental
applications. Thermodynamics, first and second laws, thermochemistry,
chemical equilibrium, solutions, kinetic theory, reaction kinetics.
Prerequisite: Chem. 126 or consent of instructor. (W)
131. Physical Chemistry (4) Thermodynamics,
chemical equilibrium, phase equilibrium, chemistry of solutions. Prerequisites:
Chem. 6C, Math. 20AB and Math. 20C or 21C and Phys. 2AB. Recommended:
Math. 20D or 21D and Phys. 2D (may be taken concurrently); or consent
of instructor. (F)
132. Physical Chemistry (4) Chemical statistics,
kinetic theory, reaction kinetics. Prerequisites: Chem. 131, Math.
20D or 21D; or consent of instructor. Recommended: Phys. 2D. (W)
133. Physical Chemistry (4) Quantum mechanics,
atomic and molecular spectroscopy, molecular structure. Prerequisites:
Chem. 132 and Phys. 2D; or Chem. 6C, Math. 20D or 21D and Math. 20F,
and Phys. 2AB; or consent of instructor. (S)
134. Computer Programming in Chemistry (4) Use
of computer programming in the analysis and presentation of chemical
data (statistical analysis, least squares fitting procedures, titration
curve interpretation, analysis of radioactive decay series, chemical
kinetics, organic synthesis, etc.) Prerequisites: Math. 20A and 20B
or equivalent. (Note: Students may not receive credit for both Chem.
134 and BIBC 115.) (May not be offered every year.)
135. Molecular Spectroscopy (4) Time-dependent
behavior of systems; interaction of matter with light; selection rule.
Radiative and nonradiative processes, coherent phenomena, and the density
matrices. Instrumentation, measurement, and interpretation. Prerequisites:
Chem. 133 or equivalent; Math. 20D or Chem. 190/290. (May not be
offered every year.)
140A. Organic Chemistry (4) An introduction
to organic chemistry, with emphasis on material fundamental to biochemistry.
Topics include bonding theory, isomerism, stereochemistry, chemical
and physical properties, and an introduction to substitution, addition,
and elimination reactions. Prerequisite: Chem. 6C or equivalent course
in general chemistry. (Note: Students may not receive credit for
both 140A and 141A.) (F,W,S)
140B. Organic Chemistry (4) A continuation
of 140A; acid/base reactions, chemistry of the carbonyl group, sugars,
peptides, nucleic acids and other natural products. Prerequisite:
Chem. 140A (a grade of C or higher in Chem. 140A is strongly recommended).
(Note: Students may not receive credit for both 140B and 141B.) (F,W,S)
140C. Organic Chemistry (4) A continuation
of Chemistry 140A-B. Organic chemistry of biologically important molecules:
carbohydrates, proteins, fatty acids, biopolymers, natural products,
drugs; models for enzymatic reactions, synthetic methods, and methods
of analysis. Prerequisite: Chem. 140B. (Note: Students may not
receive credit for both 140C and 141C.) (F,W,S)
141A. Organic Chemistry (4) Chem. 141A introduces
theoretical and experimental studies of structure and properties of
covalent molecules. Both resonance and simple molecular orbital descriptions
of organic compounds are introduced and spectroscopic methods for determining
electronic and molecular structure are discussed. Organic reactions
are introduced with synthetic and mechanistic examples. Prerequisites:
Chem. 6C (6C may be taken concurrently by good students). Prior or concurrent
physics recommended. (Note: Students may not receive credit for
both Chem. 141A and Chem. 140A.) (F)
141B. Organic Chemistry (4) A continuation
of 141A, this course applies the structure-reactivity, spectroscopy,
and electronic theories introduced in 141A to organic reactions. Prerequisite:
Chem. 141A. (Note: Students may not receive credit for both Chem.
141B and Chem. 140B.) (W)
141C. Organic Chemistry (4) A continuation
of 141A-B, this course treats selected topics such as carbon-metal bonds,
organometallic chemistry, electrophilic reactions, free radical reactions,
alkane chemistry, polymerization, molecular orbital theory and electrocyclic
reactions, photochemistry, unstable intermediates such as carbenes,
benzyne, etc., and metal oxidation reactions, and an introduction to
carbohydrate and protein chemistry. Prerequisite: Chem. 141B.
(Note: Students may not receive credit for both Chem. 141C and Chem.
140C.) (S)
143A. Organic Chemistry Laboratory (4) Introduction
to laboratory techniques needed in organic chemistry. Stresses physical
methods including separation and purification, spectroscopy, product
analysis and effects of reaction conditions. Prerequisites: Chem.
6BL, Chem. 141A or Chem. 140A. (Note: Students may not receive credit
for both Chem. 143A and Chem. 143AM.) A materials fee is required for
this course. (F,W,S)
143AM. Majors Organic Chemistry Laboratory (4) An
organic chemistry laboratory intended for chemistry majors only. It
is similar to Chem. 143A, but with emphasis on instrumental methods
of product identification, separation, and analysis. Prerequisites:
Chem. 6BL; Chem. 141A. (Note: Students may not receive credit for
both Chem. 143AM and Chem. 143A.) A materials fee is required for this
course. (W)
143B. Organic Chemistry Laboratory (4) Continuation
of 143AM or 143A, emphasizing synthetic methods of organic chemistry
for chemistry majors only. Prerequisites: Chem. 143A; 141B or 140B
(may be taken concurrently). A materials fee is required for this
course. (W,S)
143C. Organic Laboratory (5) Identification
of unknown organic compounds by a combination of chemical and physical
techniques for chemistry majors only. Prerequisites: Chem. 6CL, 143A,
141C (may be taken concurrently); 143B suggested. A materials fee
is required for this course. (F)
149A. Environmental Chemistry (4) The chemical
basis of air and water pollution, chlorofluorocarbons and the ozone
hole, the environmental impact of radioactive waste disposal, mineral
resource usage, and nuclear energy. Prerequisites: Chem. 6A-B-C.
(F)
149B. Environmental Chemistry (4) Agricultural
productivity, biological impact on the environment, deforestation, environmental
disasters (fires, nuclear winter, and volcanoes), and organic waste
handling. Prerequisite: Chem. 149A. (W)
152. Synthetic Methods in Organic Chemistry (4) (Formerly
Chem. 148) A survey of reactions of particular utility in the organic
laboratory. Emphasis is on methods of preparation of carbon-carbon bonds
and oxidation reduction sequences. Prerequisites: Chem. 140C or Chem.
141C or consent of instructor.
153. Topics in Biophysics/Photobiology (4) Basic
principles of photobiology and photochemistry. Photochemical mechanisms
in photosynthesis. Photoreceptor pigment systems and photobiological
control mechanisms in living organisms. Prerequisite: upper-division
standing in biology, chemistry, or physics, or consent of the instructor.
(Same as BIBC 153, Phys. 153.)
154. Mechanisms of Organic Reactions (4) (Formerly
Chem. 147) A qualitative approach to the mechanisms of various organic
reactions; substitutions, additions, eliminations, condensations, rearrangements,
oxidations, reductions, free-radical reactions, and photochemistry.
Includes considerations of molecular structure and reactivity, sythetic
methods, spectroscopic tools, and stereochemistry. The topics emphasized
will vary from year to year. This is the first quarter of the advanced
organic chemistry sequence. Chem. 254 students will be required to complete
additional coursework beyond that expected of students in Chem. 154.
Prerequisites: Chem. 140C or Chem. 141C or graduate standing.
155. Synthesis of Complex Molecules (4) (Formerly
Chem. 144) This course discusses planning economic routes for the synthesis
of complex organic molecules. The uses of specific reagents and protecting
groups will be outlined as well as the control of stereochemistry during
a synthesis. Examples will be selected from the recent literature. (May
not be offered every year.) Prerequisites: Chem. 152 or 252 or consent
of instructor.
156. Structure and Properties of Organic Molecules (4) (Formerly
Chem. 145) Introduction to the measurement and theoretical correlation
of the physical properties of organic molecules. Topics covered include
molecular geometry, molecular-orbital theory, orbital hybridization,
aromaticity, chemical reactivity, stereochemistry, infrared and electronic
spectra, photochemistry, and nuclear magnetic resonance. Prerequisites:
Chem. 140ABC or 141ABC or the equivalent.
157. Bioorganic and Natural Products Chemistry (4) (Formerly
Chem. 142) A comprehensive survey of modern bioorganic and natural products
chemistry. Topics will include biosynthesis of natural products, molecular
recognition, and small molecule-biomolecule interactions. Prerequisites:
Chem. 140C, 141C or consent of the instructor.
168. Bioenergetics (4) Chemiosmotic processes
in mitochondria and photosynthetic organelles, structure-function relationships
of membrane protein apoptosis, a refined view of mitochondrial structure
deduced from electron tomography, and the role of proteins encoded by
mitochondrial DNA in oxidative phosphorylation. Prerequisites: Chem.
114 A and Chem. 114B (or equivalents.)
170. Cosmochemistry (4) Composition of stars,
of planets, of meteorites, and the earth and moon. Nuclear stability
rules and isotopic composition of the elements. Chemical properties
of solar matter. Origin of the elements and of the solar system Prerequisite:
general chemistry sequence.
171. Nuclear and Radiochemistry (4) Radioactive
decay, stability systematics, neutron activation, nuclear reactions.
Szilard-Chalmers reactions, hot-atom chemistry, radiation chemistry,
effects of ionizing radiation. Prerequisite: general chemistry sequence.
173. Atmospheric Chemistry (4) Chemical principles
applied to the study of atmospheres. Atmospheric photochemistry, radical
reactions, chemical lifetime determinations, acid rain, greenhouse effects,
ozone cycle, and evolution are discussed. Prerequisites: Chem. 6A-6C.
(S)
185. Introduction to Computational Chemistry (4) This
course in computational methods builds on a background in mathematics
and physical chemistry. After a brief introduction and background in
computational theory, topics will include molecular mechanics, semi-empirical
methods, and ab initio-based methods of increasing elaboration. Emphasis
will be on applications and reliability. Prerequisites: Chem. 126
or 133 and Math. 20C. (May not be offered every year.)
190. Mathematical Methods of Chemistry (4) Applied
mathematics useful for kinetics, thermodynamics, statistical mechanics
and quantum mechanics. Topics include ordinary and partial differential
equations, special functions, probability and statistics, vector functions
and operators, linear algebra, and group theory. Prerequisites: general
chemistry, one year of calculus. (May not be offered every year.)
195. Methods of Teaching Chemistry (4) An
introduction to teaching chemistry. Students are required to attend
a weekly class on methods of teaching chemistry, and will teach a discussion
section of one of the lower-division chemistry courses. Attendance at
lecture of the lower-division course in which the student is participating
is required. (P/NP grades only.) Prerequisite: consent of instructor.
(F,W,S)
196. Reading and Research in Chemical Education (2 or 4) Independent
literature or classroom research by arrangement with, and under the direction
of, a member of the Deparment of Chemistry faculty. Students must register
on a P/NP basis. Prerequisites: upper-division standing, 2.5 minimum
GPA, consent of instructor and department.
199. Reading and Research (2 or 4) Independent
literature or laboratory research by arrangement with, and under the
direction of, a member of the Department of Chemistry faculty. Students
must register on a P/NP basis. Prerequisites: upper-division standing,
2.5 minimum GPA, consent of instructor and department. (F,W,S)
Graduate
206. Topics in Biophysics and Physical Biochemistry (4) Selection
of topics of current interest. Examples: primary processes of photosynthesis;
membrane biophysics; applications of physical methods to problems in
biology and chemistry, e.g., magnetic resonance, x-ray diffraction,
fluctuation spectroscopy, optical techniques (fluorescence, optical
rotary dispersion, circular dichroism). Topics may vary from year to
year. Prerequisite: consent of instructor. (W)
207. Modern NMR Methods (4) Treats varied
pulse sequences, one- and two-dimensional methods, interpretation of
relaxation rates, spin-decoupling, multiple quantum filtering, and solvent
suppression with application to liquid crystals, membranes, small molecules,
proteins, and nucleic acids. (May not be offered every year.)
208. Modern Methods in Protein NMR (4) This
course covers modern methods in protein NMR including multinuclear,
multidimensional (2-, 3-, and 4D) and gradient enhanced spectroscopy.
Experiments covered include, but are not limited to, 1H-15N HSQC, 15N
edited Tocsy and Noesy, HDDH-Tocsy and 1H-15N-13C correlated experiments.
Students will be able to write complete pulse sequences from the primary
literature for implementation on a Bruker spectrometer by the end of
the quarter. Prerequisite: Chem. 207. (May not be offered every
year.) (S)
211. Metabolic Biochemistry (4) A comprehensive
course in biochemistry emphasizing metabolic and human biochemistry.
Prerequisites: physical and organic chemistry; graduate-student standing.
(F)
212. Biochemistry of Growth Regulation and Oncogenesis (4) An
introduction to the biochemistry of growth regulation and oncogenesis.
Topics include: tryosine protein kinases; growth factor receptors; control
of cell proliferation; transformation by papovaviruses and retroviruses.
Designed for graduate students, but suitable for undergraduates with
consent of instructor. Prerequisite: biochemistry, molecular biology,
or equivalent. (May not be offered every year.)
213. Chemistry of Macromolecules (4) A discussion
of the structural principles governing biological macromolecules, the
techniques used in their study, and how their functional properties
depend on three-dimensional structure. Prerequisites: elementary
physical and organic chemistry. (May not be offered every year.)
214. Molecular and Cellular Biochemistry (4) This
course represents a continuation of 114C, or an introductory course
for first- and second-year graduate students, and covers topics in molecular
and cellular biochemistry. Emphasis will be placed on contemporary approaches
to the isolation and characterization of mammalian genes and proteins,
and molecular genetic approaches to understanding eukaryotic development
and human disease. Prerequisite: Chem. 114A-C or consent of instructor.
(May not be offered every year.)
215. Modeling Biological Macromolecules (4) Use
of computer graphics and modeling methods in the study of biological
macromolecules. The course will cover basic methods and techniques.
The objective is to provide a good working knowledge of the critical
features of the methods and to provide a foundation for further study
for those who wish to pursue these methods as research topics. Prerequisite:
Chem. 114A or equivalent. (May not be offered every year.)
216. Chemistry of Enzyme Catalyzed Reactions (4) A
discussion of the chemistry of representative enzyme catalyzed reactions
is presented. Enzyme reaction mechanisms and coenzyme chemistry are
emphasized. Prerequisite: organic chemistry. (May not be offered
every year.)
217. Immunology (3) Graduate students will
explore topics in specialized areas of immunochemistry and cellular
immunology, antigenic and molecular structure of immunoglobulin molecules;
antigenantibody interactions; cellular events in the humoral and cellular
immune responses; translation immunology. Prerequisite: consent of
instructor. (F) (Not offered in 200203.)
218. Macromolecular Biochemistry (4) A comprehensive
course in biochemistry emphasizing structural biochemistry. Prerequisites:
physical and organic chemistry; graduate-student standing. (F)
219A-B-C. Special Topics in Biochemistry (4-4-4) This
special topics course is designed for first-year graduate students in
biochemistry. Topics presented in recent years have included protein
processing, the chemical modification of proteins, the biosynthesis
and function of glycoproteins, lipid biochemistry and membrane structure,
and bioenergetics. Prerequisites: undergraduate courses in biochemistry.
(May not be offered every year.)
221. Signal Transduction (4) The aim of this
course is to develop an appreciation for a variety of topics in signal
transduction. We will discuss several historical developments while
the focus will be on current issues. Both experimental approaches and
results will be included in our discussions. Topics may vary from year
to year. Prerequisites: biochemistry and molecular biology. (May
not be offered every year.)
222. Structure and Bonding of Solids (4) Key
concepts in the atomic structure and bonding of solids such as metals,
ceramics, and semiconductors. Symmetry operations, point groups, lattice
types, space groups, simple and complex inorganic compounds, structure/property
comparisons, structure determination with X-ray diffraction. Ionic,
covalent, metallic bonding compared with physical properties. Atomic
and molecular orbitals, bands versus bonds, free electron theory.
223. Organometallic Chemistry (4) A survey
of this field from a synthetic and mechanistic viewpoint. Reactivity
patterns for both main group and transition element organometallic compounds
will be discussed and organized to periodic trends. (May not be offered
every year.)
224. Spectroscopic Techniques (4) Application
of physical techniques to the elucidation of the structure of inorganic
complex ions and organometallic compounds. Topics covered include group
theory, and its application to vibrational, magnetic resonance and Raman
spectroscopy. (May not be offered every year.)
225. Bioinorganic Chemistry (4) The role of
metal ions in biological systems, with emphasis on transition metal
ions in enzymes that transfer electrons, bind oxygen, and fix nitrogen.
Also included are metal complexes in medicine, toxicity, and metal ion
storage and transport. (May not be offered every year.)
226. Mechanistic Aspects of Catalytic Reactions (4) Mechanisms
of substitution and electron transfer reaction of inorganic complexes
will be examined from an experimental point of view. A quantitative
treatment of rate laws, the steady state approximation and multistep
mechanisms of reactions that are catalyzed by soluble transition metal
complexes. (May not be offered every year.)
227. Seminar in Inorganic Chemistry (2) Seminars
presented by faculty and students on topics of current interest in inorganic
chemistry, including areas such as bioinorganic, organometallic and
physical-inorganic chemistry. The course is designed to promote a critical
evaluation of the available data in specialized areas of inorganic chemistry.
Each quarter three or four different topics will be discussed. Prerequisite:
graduate standing or consent of instructor.
229. Special Topics in Inorganic Chemistry (2-4) (May
not be offered every year.)
230. Quantum Mechanics (4) Concepts and mathematical
formalism that are useful for problems of chemical interest: states,
representations, operators, eigenvalues and eigenfunctions, time evolution,
observables, and measurements. Time- independent perturbation theory.
Prerequisites: Chem. 133 or equivalent; Math. 20D or equivalent;
Chem. 190 may be taken concurrently. (May not be offered every year.)
231. Chemical Kinetics and Molecular Reaction Dynamics (4)
Classical kinetics, transition state theory, unimolecular decomposition,
potential energy surfaces; scattering processes and photodissociation
processes. Prerequisite: Chem. 230. (May not be offered ever
year.)
232. Statistical Mechanics of Chemical Systems (4)
Equilibrium statistical mechanics, distribution functions, and partition
functions. Boltzman, Bose, and Fermi statistics. The different ensembles;
ensemble averages and QM expectation values; derivation of thermodynamic
properties of simple systems. Prerequisites: Chem. 133, 131 and 132,
or equivalent. (May not be offered every year.)
234. Thermodynamics (4) Thermodynamics of
chemical systems; the three laws, with emphasis on the formal structure
of thermodynamics. Chemical equilibrium, stability theory, heterogeneous
equilibrium, solutions. Prerequisites: Chem. 131, 132 or equivalent.
(May not be offered every year.)
235. Molecular Spectroscopy (4) Time-dependent
behavior of systems; interaction of matter with light; selection rule.
Radiative and nonradiative processes, coherent phenomena and the density
matrices. Instrumentation, measurement, and interpretation. Prerequisites:
Chem. 133 or equivalent; Math. 20D or 21D; or Chem. 190/290. (May
not be offered every year.)
236. Atherosclerosis (2) This multidisciplinary
course integrates the studies of the pathogenesis of atherosclerosis,
with emphasis on lipoprotein metabolism, and the cellular and biochemical
mechanisms of lesion development. Two-hour lectures. Same as Medicine
236. Prerequisite: biochemistry. (May not be offered every year.)
237. Essentials of Glycobiology (2) Advanced
elective for graduate/medical students who have had core courses in
cell biology or biochemistry. Expert faculty will present a coordinated
overview of the field of glycobiology, which explores the structure,
synthesis, and functions of sugar chains in biological systems. (May
not be offered every year.) (Not offered in 200203.)
238. Current Topics in Physical Chemistry (4)
Critical reading of current literature; training and practice in presenting
oral reports, writing scientific papers and proposals. (May not be offered
every year.)
239. Special Topics in Chemical Physics (4)
Topics of special interest will be presented. Examples include NMR,
solid-state chemistry, phase transitions, stochastic processes, scattering
theory, nonequilibrium processes, tensor transformations, and advanced
topics in statistical mechanics, thermodynamics, and chemical kinetics.
(May not be offered every year.)
240. Electrochemistry (4) Application of electrochemical
techniques to chemistry research. Basic electrochemical theory and instrumentation:
the diffusion equations, controlled potential, and current methods.
Electro-chemical kinetics, Butler-Volmer, Marcus-Hush theories, preparative
electrochemistry, analytical electrochemistry, solid and polymer electrolytes,
semiconductor photoelectrochemistry. (May not be offered every year.)
246. Kinetics and Mechanism (4) Methodology
of mechanistic organic chemistry: integration of rate expressions, determination
of rate constants, transition state theory; catalysis, kinetic orders,
isotope effects, substitute effects, solvent effects, linear free energy
relationship; product studies, stereochemistry; reactive intermediates;
rapid reactions. (May not be offered every year.)
247. Mechanisms of Organic Reactions (4) A
qualitative approach to the mechanism of various organic reactions;
substitutions, additions, eliminations, condensations, rearrangements,
oxidations, reductions, free-radical reactions, and photochemistry.
Includes considerations of molecular structure and reactivity, synthetic
methods, spectroscopic tools, and stereochemistry. The topics emphasized
will vary from year to year. This is the first quarter of the graduate
organic chemistry sequence. Prerequisite: Chem. 141C.
249. Special Topics in Organic Chemistry (2-4)
(May not be offered every year.)
250. Seminar in Chemistry (2) Regularly scheduled
seminars by first-year graduate students provide opportunities for practice
in seminar delivery and for the exploration of topics of general interest.
(S/U grades only.) (S)
251. Research Conference (2) Group discussion
of research activities and progress of the group members. Prerequisite:
consent of instructor. (S/U grades only.) (F,W,S)
252. Synthetic Methods in Organic Chemistry (4)
(Formerly CHEM 248) A survey of reactions of particular utility in the
organic laboratory. Emphasis is on methods of preparation of carbon-carbon
bonds and oxidation reduction sequences. Prerequisites: Chemistry
141C or consent of instructor.
254. Mechanisms of Organic Reactions (4) (Formerly
Chem. 247) A qualitative approach to the mechanisms of various organic
reactions; substitutions, additions, eliminations, condensations, rearrangements,
oxidations, reductions, free-radical reactions, and photochemistry.
Includes considerations of molecular structure and reactivity, sythetic
methods, spectroscopic tools, and stereochemistry. The topics emphasized
will vary from year to year. This is the first quarter of the advanced
organic chemistry sequence. Chem. 254 students will be required to complete
additional coursework beyond that expected of students in Chem. 154.
Prerequisites: Chem. 140C or Chem. 141C or graduate standing.
255. Synthesis of Complex Molecules (4) (Formerly
Chem. 244) This course discusses planning economic routes for the synthesis
of complex organic molecules. The uses of specific reagents and protecting
groups will be outlined as well as the control of stereochemistry during
a synthesis. Examples will be selected from the recent literature. (May
not be offered every year.) Prerequisites: Chem. 152 or 252.
256. Structure and Properties of Organic Molecules (4)
(Formerly Chem. 245) Introduction to the measurement and theoretical
correlation of the physical properties of organic molecules. Topics
covered include molecular geometry, molecular-orbital theory, orbital
hybridization, aromaticity, chemical reactivity, stereochemistry, infrared
and electronic spectra, photochemistry, and nuclear magnetic resonance.
Prerequisites: Chem. 140ABC or 141ABC or the equivalent.
257. Biorganic and Natural Products Chemistry (4)
(Formerly Chem. 242) A comprehensive survey of modern bioorganic and
natural products chemistry. Topics include biosynthesis of natural products,
molecular recognition, and small molecule-biomolecule interactions.
Prerequisites: Chem. 140C, 141C, 254 or consent of instructor.
258. Applied Spectroscopy (4) Intensive coverage
of modern spectroscopic techniques used to determine the structure of
organic molecules. Problem solving and interpretation of spectra will
be strongly emphasized. Prerequisites: Chem. 254 or consent of instructor.
259. Special Topics in Organic Chemistry (2-4)
Various advanced topics in organic chemistry. Includes but is not limited
to: advanced kinetics, advanced spectroscopy, computational chemistry,
heterocyclic chemistry, medicinal chemistry, organotransition metal
chemistry, polymers, solid-phase synthesis/combinatorial chemistry,
stereochemistry, and total synthesis classics.
262. Inorganic Chemistry and NMR (4) A survey
of inorganic chemistry to prepare for graduate research in the field,
including a detailed introduction to nuclear magnetic resonance (NMR),
followed by applications of NMR to structural and mechanistic problems
in inorganic chemistry.
268. Bioenergetics (4) Chemiosmotic processes
in mitochondria and photosynthetic organelles, structure-function relationships
of membrane protein apoptosis, a refined view of mitochondrial structure
deduced from electron tomography and the role of proteins encoded by
mitochondrial DNA in oxidative phosphorylation. Prerequisites: Chem.
114 A and Chem. 114B (or equivalents.)
270A-B-C. Current Topics in Environmental Chemistry (2-2-2)
Formal lecture series on the current topics in the field of environmental
chemistry. Emphasis is on current research topics in atmospheric, oceanic,
and geological environments. Prerequisite: consent of instructor.
(May not be offered every year.)
285. Introduction to Computational Chemistry (4)
This course in computational methods builds on a background in mathematics
and physical chemistry. After a brief introduction and background in
computational theory, topics will include molecular mechanics, semi-empirical
methods, and AB initio-based methods of increasing elaboration. Emphasis
will be on applications and reliability. Prerequisites: Chem. 126
or 133 and Math. 20C. (May not be offered every year.)
290. Mathematical Methods in Chemistry I (4)
Applied mathematics useful in kinetics, spectroscopy, thermodynamics,
statistical mechanics, and quantum mechanics; ordinary and partial differential
equations, vector spaces, operators, linear algebra, numerical analysis.
Prerequisites: general chemistry, calculus. (May not be offered
every year.)
293. Cosmochemistry Seminar (2) Formal seminars
or informal sessions on topics of current interest in cosmochemistry
as presented by visiting lecturers, local researchers, or students.
Prerequisite: advanced graduate-student standing. (S/U grades
only.)
294. Organic Chemistry Seminar (2) Formal
seminars or informal puzzle sessions on topics of current interest in
organic chemistry, as presented by visiting lecturers, local researchers,
or students. Prerequisite: advanced graduate-student standing.
(S/U grades only.) (F,W,S)
295. Biochemistry Seminar (2) Formal seminars
or informal puzzle sessions on topics of current interest in biochemistry,
as presented by visiting lecturers, local researchers, or students.
Prerequisite: advanced graduate-student standing. (S/U grades
only.)
296. Chemical Physics Seminar (2) Formal seminars
or informal sessions on topics of current interest in chemical physics
as presented by visiting lecturers, local researchers, or students.
Prerequisite: advanced graduate-student standing. (S/U grades
only.) (F,W,S)
297. Experimental Methods in Chemistry (4)
Experimental methods and techniques involved in chemical research are
introduced. Hands-on experience provides training for careers in industrial
research and for future thesis research. Prerequisite: graduate standing.
298. Special Study in Chemistry (1-4) Reading
and laboratory study of special topics under the direction of a faculty
member. Exact subject matter to be arranged in individual cases. (S/U
grades only.) Credit is limited to four units per quarter. (F,W,S)
299. Research in Chemistry (1-12) Prerequisites:
graduate standing and consent of instructor. (S/U grades only.)
(F,W,S)
500. Teaching in Chemistry (4) A doctoral
student in chemistry is required to assist in teaching undergraduate
chemistry courses. One meeting per week with instructor, one or more
meetings per week with assigned class sections or laboratories, and
attendance at the lecture of the undergraduate course in which he or
she is participating. Prerequisites: graduate standing and consent
of instructor. (S/U grades only.) (F,W,S)
Chemistry and Biochemistry Courses
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