Courses202. Carcinogenesis and Drug Metabolism (3) This elective will explore relationships between drug metabolism and carcinogenesis at cellular, molecular and etiological levels. Guided by faculty, students will research and present key papers and principles underlying the biochemistry, genetics, biophysics, and computer-assisted aspects of several assigned topics. Prerequisites: biology and chemistry. Cell biology, biochemistry, and molecular biology may be taken concurrently. 204. Evolution of Modern Concepts in Pharmacology (2) This course details the evolution of modern principles of pharmacology from first evidences to the present level of knowledge. The course will be independent of but compliment general principles of pharmacology courses for medical and graduate students. Prerequisites: prior or concurrent Principles of Pharmacology, or equivalent course. 206. Organ Physiology (9) Building on the student’s basic knowledge of cellular biology and biochemistry, this course develops fundamental concepts of organ physiology. Major areas include autonomic, cardiovascular, gastrointestinal, renal, and respiratory physiology. Clinical correlation sessions relate physiological principles to clinical situations. Prerequisites: BMS 210, 211, 212, 213 or equivalent background in biology and chemistry. For students not in the School of Medicine, consent of instructor. (W) 206L. Organ Physiology and Pharmacology, Laboratory Course (3) Selected laboratory exercises demonstrating basic principles of pharmacology and organ physiology. Subjects covered include electrocardiography, hemodynamics, myocardial control mechanisms, pulmonary function, dose-response relationships in pharmacology, autonomic mechanisms, and other aspects of physiology and pharmacology. Prerequisites: cell biology and biochemistry or equivalent, and consent of instructor. (W) 207. Using Internet Resources in Molecular Biology (2) Increasing the Internet is a source both of data and analysis tools in molecular biology. A hands-on series of instructional lectures is proposed that uses these resources to work through problems found in many molecular biology research situations. Topics include: DNA and protein sequence analysis, genome analysis, constructing and using phylogenetic trees, RNA structure prediction, protein structure analysis, classification and prediction. Prerequisites: consent of instructor. 219. Ethics in Scientific Research (1) Overview of ethical issues in scientific research, conflicts of interest; national, statewide and campus issues and requirement; ethical issues in publications; authorship; retention of research records; tracing of research records; attribution; plagiarism; copyright considerations; primary, archival and meeting summary publications; ethical procedures and policies; NIH, NSF, California and UCSD; case studies and precedents in ethics. Prerequisites: permission of instructor. 222. Essentials of Glycobiology (2) Advanced elective for graduate/medical students who have had core courses in cell biology or biochemistry. Expert faculty will present a coordinated overview of the field of glycobiology, which explores the structure, synthesis and functions of sugar chains in biological systems. 223. Genetics, Metabolism, and Inherited Disease (2) Detailed discussions of the molecular aspects of certain inborn errors of intermediary metabolism selected to illustrate principles of biochemical genetics applicable to a wider variety of clinically important genetic diseases. Individual sessions will include faculty presentations followed by student-led discussions of the particular principles illustrated by the disorders reviewed. (S) 224. Topics in Cancer Research (2) Each quarter will focus on an important area of cancer research such as immunology (fall), growth regulation (winter), and cancer genetics (spring). One-hour lecture coordinated with a one-hour seminar with the opportunity to meet with the invited speaker. Prerequisites: senior undergraduates, graduate students, medical students. (W,S) 226. Frontiers in Endocrinology and Metabolism (3) The course covers recent advances of research in lipid, lipoprotein metabolism, carbohydrate metabolism, reproductive medicine, diabetes mellitus, and atherosclerosis. (F) 228. Basic Science Research Seminar (1) The objective is to provide an opportunity for cardiology research fellows, postgraduate students and undergraduate students to intereact with faculty in the Division of Cardiology in a faculty-sponsored basic research seminar. This will take place once a month for ten sessions at a faculty member’s home. It will be in the format of a journal club where a faculty member or a faculty-sponsored individual will present and discuss one recent article deemed to have considerable scientific importance. The content of the course will be determined by the faculty member who is assigned the session. Prerequisite: bachelor’s degree in a science discipline. (F,W,S) 229. Methods in Pharmacology (3) A combination of lecture and lab exercises presented by the faculty of the Group in Biomedical Sciences, designed to introduce biomedical science graduate students to the essential techniques employed in molecular and cellular pharmacology. Prerequisites: BMS 212, OP, CBB, biochemistry, molecular biology, biomedical sciences or consent of instructor. (S) 230. Receptors and Signal Transduction (3) An examination of the molecular and biochemical bases of drug and neurotransmitter action. Topics include molecular basis of drug specificity, receptor mechanisms, neuropharmacology, signal transduction from the cell surface to the nucleus, and drug action on excitable tissues. Prerequisite: course in biochemistry. (F) 231. Contemporary Topics in Pharmacology (2) A selection of short courses in the biomedical and pharmacological sciences offered by resident experts. Topics will vary annually. Each short course will last one to two weeks, meeting five hours a week. Prerequisite: consent of instructor. (F,W,S) (Not offered in fall 1997.) 233. Molecular Biology of Human Retroviruses (3) Replication cycle and gene regulation of HIV. Molecular approaches to therapy and vaccines. Prerequisites: undergraduates lower-division courses in Biology, BIMM 100, BICD 100, BIBC 100, BIBC 102. 236. Maternal and Placental Physiology (2) This course provides a broad based coverage of the physiology of maternal changes during pregnancy as well as physiology of the placenta. Included are endocrine, cardiovascular, respiratory, fluid balance, metabolism, nutrition, lactation, immune and postpartum aspects as well as problems of pregnancy. Prerequisites: Med. 206 (OPP) and Med. 209 (ERM), or equivalent. (F) 237. Fetal Physiology (2) This course provides a broad based coverage of the physiology of the fetus, including growth and development, metabolism, neurologic and endocrine development, regulation of the cardiovascular, endocrine, renal, and gastrointestinal systems, development of the lungs, immune system, abnormal development genetic problems, and diseases. Prerequisites: same as 236. (W) 240. Critical Reading in Cell Biology (3) This course will focus on critical reading and understanding current areas in Cell and Molecular Biology. The exact topic will vary, but will include such topics as Protein Trafficking, Cell Division, Intracellular Movement, Cell Interaction, and Cell Cycle. 242. Seminar in Genetics (1) Intended for graduate students interested in principles of classical and molecular genetics. Will attend weekly genetics seminar and participate in didactic/discussion preparatory session. Prerequisite: consent of instructor. 243. Human Genetics (3) Advanced aspects of human genetics and human genetics disease, including principles of Mendelian and non-Mendelian inheritance, monogenic and polygenic traits, anticipation, penetrance, and genomics. Course will consist of alternating didactic sessions and seminars in which students will present papers. 245. Cancer Genetics (3) Intended for graduate students interested in genetics. Course will cover genetic basis for cancer related diseases. Prerequisites: graduate-level course in cell biology and molecular biology. 250. Molecular and Modern Methodologies in Physiological Sciences (2) This course emphasizes modern approaches and methodologies for investigating physiological processes in normal and pathological conditions. This includes the application of transgenic, knockout, adenovirus gene therapy, antisense, and cellular imaging technologies in animal models. 260. Immune Regulation (3) This course will cover most of today’s key aspects in the organization and dynamics of the immune system and its regulation. It will provide students with a basis for understanding the physiology and functioning of the immune system in normal and pathological states. Prerequisites: core courses in Biomedical Sciences Ph.D. Program, or permission of instructor. 262. Neurophysiology (4) An overview of neurophysiological systems, emphasizing mammalian neurophysiology and related model vertebrate systems and concepts. (W) 264. Molecular and Cellular Basis of Disease (2) Lectures on the molecular and cellular mechanisms of pathogenesis. Topics will include Alzheimer’s disease, cell surface and unclear receptors in disease, signal transduction by oncogenes in cancer cells, AIDS, human diseases affecting glycosylation pathways, rheumatoid arthritis, and arteriosclerosis. Prerequisite: graduate students. (W) 271. Cardiovascular Physiology (4) Physical concepts of behavior of heart, large blood vessels, vascular beds in major organs, and the microcirculation. Physical and physiological principles of blood flow, blood pressure, cardiac work, electrophysiology of the heart. Special vascular beds, including their biological and hemodynamic importance. Integration through nervous and humoral controls. Prerequisites: BIPN 100, 102 and BE 231A, or consent of instructor. 282. Microbial Pathogenesis (3) Topics covered in this course include molecular and cellular mechanisms of viral, bacterial, and protozoan pathogenesis. Host response and microbial mechanisms of evasion of host defense will also be discussed. Sessions will consist of faculty and student presentations of current literature. Prerequisite: graduate standing or consent of instructor. (S) 285. Statistical Inference in the Medical Sciences (2) An introduction to basic techniques used in biomedical literature: t tests, ANOVA, chi-square, linear and nonlinear regression. Emphasis will be on understanding the appropriate use and interpretation of the tests, rather than on the calculations. 294. Pharmacology and Molecular Biology Journal Club (0-1) Current literature in molecular pharmacology and molecular biology is reviewed. Two papers are chosen per week for oral presentation by students. Faculty critique the student presentations. Prerequisite: enrollment in Ph.D. program at year two and above. (F,W,S) 295. Pharmacology Research Discussions (0-1) Student, faculty, and fellow discussion groups on research projects. Students are expected to present research findings to fellows, other Ph.D. students, and faculty. Written critiques are provided by the faculty. Prerequisites: completion of minor proposition examination and two years of graduate work. (F,W,S) 296. Directed Reading (1-4) Reading of special topics under the direction of a faculty member. Exact subject matter to be arranged in individual cases. Prerequisite: consent of instructor. 297. Progress in Signal Transduction (1) Papers describing recent progress in signal transduction from the cell-surface to the nucleus will be chosen from recent research literature. Two papers will be discussed and criticized in detail each week for one hour. Prerequisites: graduate level Biochemistry, Cell Biology, and Molecular Biology; registered as second year and above graduate student in Biomedical Sciences, Biology, or Chemistry. (F,W,S) 298. Directed Study (1-12) Reading and laboratory study of special topics under the direction of a faculty member. Exact subject matter to be arranged in individual cases. (F,W,S) 299. Independent Study or Research (1-12) Independent study or research. Prerequisite: consent of instructor. (F,W,S) |
